Publication Name	World Journal of Clinical Oncology
Manuscript ID	108377
Country	Romania

Received	2025-04-14 03:39
Peer-Review Started	2025-04-14 03:39
To Make the First Decision
Return for Revision	2025-05-17 07:31
Revised	2025-05-24 09:01
Second Decision	2025-09-01 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-02 01:15
Articles in Press	2025-09-02 01:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-28 02:37
Publish the Manuscript Online	2025-10-24 06:10

ISSN	2218-4333 (online)
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Category	Surgery
Manuscript Type	Editorial
Article Title	From infection to invasion: The role of deleted in malignant brain tumors 1 in Helicobacter pylori-driven gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Ionut Negoi
Funding Agency and Grant Number
Corresponding Author	Ionut Negoi, Associate Professor, Head, MD, PhD, Department of General Surgery, Carol Davila University of Medicine and Pharmacy Bucharest, Clinical Emergency Hospital of Bucharest, No. 8 Floreasca Street, Sector 1, Bucharest 014461, Romania. negoiionut@gmail.com
Key Words	Gastric cancer; Deleted in malignant brain tumors 1 expression; Helicobacter Pylori; Carcinogenesis; Infection
Core Tip	Gastric cancer (GC) remains a major global health issue closely linked to Helicobacter pylori (H. pylori) infection, which induces chronic inflammation, oxidative DNA damage, and disrupts cell cycle regulation. Cytotoxin-associated gene A plays a significant role in carcinogenesis. Deleted in malignant brain tumors 1 (DMBT1), a potential tumor suppressor, shows variable expression in GC, often being downregulated in well-differentiated adenocarcinomas and upregulated in other subtypes. DMBT1 interacts directly with H. pylori to modulate the immune response. Preserved DMBT1 expression may protect against gastric carcinogenesis, whereas its downregulation may facilitate tumor progression. Understanding the DMBT1-H. pylori interaction could help identify new therapeutic strategies for the prevention and treatment of GC.
Publish Date	2025-10-24 06:10
Citation	<p>Negoi I. From infection to invasion: The role of deleted in malignant brain tumors 1 in Helicobacter pylori-driven gastric cancer. <i>World J Clin Oncol</i> 2025; 16(10): 108377</p>
URL	https://www.wjgnet.com/2218-4333/full/v16/i10/108377.htm
DOI	https://dx.doi.org/10.5306/wjco.v16.i10.108377

Full Article (PDF)	WJCO-16-108377-with-cover.pdf
Manuscript File	108377_Auto_Edited_084631.docx
Answering Reviewers	108377-answering-reviewers.pdf
Audio Core Tip	108377-audio.m4a
Conflict-of-Interest Disclosure Form	108377-conflict-of-interest-statement.pdf
Copyright License Agreement	108377-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	108377-non-native-speakers.pdf
Supplementary Material	108377-supplementary-material.pdf
Peer-review Report	108377-peer-reviews.pdf
Scientific Misconduct Check	108377-scientific-misconduct-check.png
Scientific Editor Work List	108377-scientific-editor-work-list.pdf
CrossCheck Report	108377-crosscheck-report.pdf