Publication Name	World Journal of Gastroenterology
Manuscript ID	108617
Country	China

Received	2025-04-24 13:34
Peer-Review Started	2025-04-24 13:34
To Make the First Decision
Return for Revision	2025-05-10 04:32
Revised	2025-05-22 01:02
Second Decision	2025-08-13 05:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-13 08:19
Articles in Press	2025-08-13 08:19
Publication Fee Transferred	2025-05-27 01:04
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-02 03:48
Publish the Manuscript Online	2025-09-05 06:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Dopamine receptor D1-mediated suppression of liver fibrosis via Hippo/Yes-associated protein 1 signaling in levodopa treatment
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Yan Wang, Man-Man Qi, Kai Zhang, Yu-Zhao Zhu and Jian Zhang
Funding Agency and Grant Number
Corresponding Author	Jian Zhang, PhD, Professor, Department of Nuclear Medicine, Universal Medical Imaging Diagnostic Center, Shanghai University, No. 168 Changhai Road, YangPu District, Shanghai 200233, China. abiaoxp@163.com
Key Words	Levodopa; Liver fibrosis; Yes-associated protein 1 transcriptional regulator; Hippo/Yes-associated protein 1 signaling pathway; Dopamine receptor D1
Core Tip	This study found that levodopa significantly alleviated CCl4-induced liver fibrosis in rats by upregulating Gα s-coupled protein dopamine receptor D1 (DRD1) expression and enhancing Yes-associated protein 1 (YAP) phosphorylation through the activation of the Hippo signaling pathway. This study for the first time demonstrates levodopa's potential as a novel therapeutic strategy targeting the DRD1-Hippo/YAP axis in liver fibrosis.
Publish Date	2025-09-05 06:36
Citation	<p>Wang HY, Qi MM, Zhang K, Zhu YZ, Zhang J. Dopamine receptor D1-mediated suppression of liver fibrosis via Hippo/Yes-associated protein 1 signaling in levodopa treatment. <i>World J Gastroenterol</i> 2025; 31(34): 108617</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i34/108617.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i34.108617

Full Article (PDF)	WJG-31-108617-with-cover.pdf
The ARRIVE Guidelines	108617-The-ARRIVE-Guidelines.pdf
Manuscript File	108617_Auto_Edited_044411.docx
Answering Reviewers	108617-answering-reviewers.pdf
Audio Core Tip	108617-audio.m4a
Biostatistics Review Certificate	108617-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	108617-conflict-of-interest-statement.pdf
Copyright License Agreement	108617-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	108617-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	108617-non-native-speakers.pdf
Peer-review Report	108617-peer-reviews.pdf
Scientific Misconduct Check	108617-scientific-misconduct-check.png
Scientific Editor Work List	108617-scientific-editor-work-list.pdf
CrossCheck Report	108617-crosscheck-report.pdf