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11/28/2025 2:03:28 PM | Browse: 17 | Download: 69
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Received |
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2025-04-20 03:43 |
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Peer-Review Started |
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2025-04-20 03:43 |
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To Make the First Decision |
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Return for Revision |
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2025-05-12 03:15 |
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Revised |
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2025-05-13 16:51 |
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Second Decision |
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2025-05-29 02:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-29 10:59 |
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Articles in Press |
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2025-05-29 10:59 |
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Publication Fee Transferred |
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2025-05-14 16:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-01 05:48 |
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Publish the Manuscript Online |
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2025-11-28 14:00 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Reactive oxygen species elevations in human immune cell subsets during sepsis are mitigated by norepinephrine and N-acetylcysteine
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Joby Thoppil, J David Farrar, Drashya Sharma, Shaun Kirby, Angela Mobley and Daniel Mark Courtney |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Emergency Medicine Foundation |
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| Zoll Foundation |
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| Corresponding Author |
Joby Thoppil, Assistant Professor, MD, PhD, Department of Emergency Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd E6.110A, Dallas, TX 75390, United States. joby.thoppil@utsouthwestern.edu |
| Key Words |
Sepsis; Reactive oxygen species; Norepinephrine; N-acetylcysteine; Peripheral blood mononuclear cells; Flow cytometry; Redox biology; Inflammation |
| Core Tip |
Sepsis is a life-threatening condition characterized by immune dysregulation, in which peripheral blood mononuclear cells are believed to play a central role. Reactive oxygen species (ROS) are critical to immune cell signaling, but excessive ROS may contribute to immune alterations during sepsis. In this observational study, we demonstrate elevated ROS levels in CD3+ T cells and CD14+ monocytes from septic patients. Using in vitro models, we show that norepinephrine and N-acetylcysteine attenuate ROS accumulation following inflammatory stimulation. These findings suggest that targeting oxidative imbalance may represent a promising direction for future sepsis research. |
| Publish Date |
2025-11-28 14:00 |
| Citation |
<p>Thoppil J, Farrar JD, Sharma D, Kirby S, Mobley A, Courtney DM. Reactive oxygen species elevations in human immune cell subsets during sepsis are mitigated by norepinephrine and N-acetylcysteine. <i>World J Crit Care Med</i> 2025; 14(4): 108638</p> |
| URL |
https://www.wjgnet.com/2220-3141/full/v14/i4/108638.htm |
| DOI |
https://dx.doi.org/10.5492/wjccm.v14.i4.108638 |
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