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9/1/2025 9:09:41 AM | Browse: 203 | Download: 155
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Received |
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2025-04-27 09:53 |
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Peer-Review Started |
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2025-04-27 09:53 |
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To Make the First Decision |
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Return for Revision |
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2025-06-23 02:17 |
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Revised |
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2025-07-05 00:18 |
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Second Decision |
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2025-08-05 02:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-05 07:23 |
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Articles in Press |
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2025-08-05 07:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-25 03:11 |
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Publish the Manuscript Online |
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2025-09-01 08:05 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Exosomes derived from human umbilical cord mesenchymal stem cells attenuate hepatic ischaemia-reperfusion injury via the let-7i-5p/Faslg axis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yao Gao, Min He, Cong-Wen Bian, Rui Yu, Jia-Jiao Luo, Yin-Ming Xiang, Yun-Xin Yang, Han-Fei Huang and Zhong Zeng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation Project of Yunnan Province |
202302AA310025 |
| Health Research Project of Yunnan Province |
300068 |
| Natural Science Foundation Project of Yunnan Province |
202449CE340016 |
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| Corresponding Author |
Han-Fei Huang, Professor, The Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Wuhua District, Kunming 650032, Yunnan Province, China. huanghanfei@kmmu.edu.cn |
| Key Words |
Mesenchymal stem cells; Exosomes; Let-7i-5p; Ischaemia-reperfusion injury; Liver |
| Core Tip |
Human umbilical cord mesenchymal stem cell-derived exosomes mitigate hepatic ischaemia-reperfusion injury by targeting damaged hepatocytes via very late activation antigen-4/vascular cell adhesion molecule-1 and lymphocyte function-associated antigen-1/intercellular adhesion molecule-1 interactions. Their membrane proteins crucially mediate this specific protection, suppressing both the extrinsic and intrinsic apoptotic pathways. Central to this mechanism is the let-7i-5p/factor-related apoptosis ligand signaling axis. |
| Publish Date |
2025-09-01 08:05 |
| Citation |
<p>Gao Y, He M, Bian CW, Yu R, Luo JJ, Xiang YM, Yang YX, Huang HF, Zeng Z. Exosomes derived from human umbilical cord mesenchymal stem cells attenuate hepatic ischaemia-reperfusion injury via the let-7i-5p/Faslg axis. <i>World J Gastroenterol</i> 2025; 31(33): 108653</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i33/108653.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i33.108653 |
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