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9/15/2025 10:16:53 AM | Browse: 104 | Download: 30
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Received |
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2025-04-21 05:15 |
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Peer-Review Started |
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2025-04-21 05:16 |
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To Make the First Decision |
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Return for Revision |
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2025-05-13 12:07 |
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Revised |
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2025-05-23 08:58 |
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Second Decision |
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2025-07-18 02:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-18 08:12 |
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Articles in Press |
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2025-07-18 08:12 |
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Publication Fee Transferred |
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2025-05-26 15:26 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-01 06:41 |
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Publish the Manuscript Online |
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2025-09-15 08:38 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
DEAD/H-box RNA helicase 10 promotes pancreatic cancer cell proliferation via ribonucleotide reductase M2
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Sheng Qiu, Xiao-Chun Wang, Ji-Chun Ma, Cheng-Lou Zhu, Yong-Li Hu and Ming-Xu Da |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82160588 |
| Health Commission of Gansu Province |
GSWSKY2021-032 |
| Natural Science Foundation of Gansu Province |
24JRRA585 |
| Gansu Provincial Hospital Science and Technology innovation platform fund project |
21GSSYB-23 |
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| Corresponding Author |
Ming-Xu Da, Professor, The First Clinical Medical College, Lanzhou University, No. 222 Tianshui South Road, Chengguan District, Lanzhou 730000, Gansu Province, China. ldyy_damx@lzu.edu.cn |
| Key Words |
RRM2; DEAD-box RNA helicase 10; Pancreatic cancer proliferation; Migration; Invasion |
| Core Tip |
This study elucidates the role of DEAD-box RNA helicase 10 (DDX10) in pancreatic cancer (PC) progression. Through bioinformatics analysis, tissue microarray evaluation, and in vitro assays, we discovered that DDX10 is overexpressed in PC tissues compared to non-tumor tissues. Knockdown of DDX10 significantly inhibited cell proliferation, invasion, and migration while promoting apoptosis. Mechanistic investigations revealed that DDX10 regulates key oncogenes, including RRM2, which counteracts the growth-inhibitory effects of DDX10 knockdown. Importantly, DDX10 expression was found to negatively correlate with patient survival rates. These findings highlight DDX10 as a potential therapeutic target for PC. |
| Publish Date |
2025-09-15 08:38 |
| Citation |
<p>Qiu ZS, Wang XC, Ma JC, Zhu CL, Hu YL, Da MX. DEAD/H-box RNA helicase 10 promotes pancreatic cancer cell proliferation via ribonucleotide reductase M2. <i>World J Gastrointest Oncol</i> 2025; 17(9): 108672</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i9/108672.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i9.108672 |
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