Publication Name	World Journal of Gastroenterology
Manuscript ID	108680
Country	China

Received	2025-05-06 11:18
Peer-Review Started	2025-05-06 11:18
To Make the First Decision
Return for Revision	2025-05-22 15:53
Revised	2025-06-16 00:53
Second Decision	2025-07-16 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-16 07:37
Articles in Press	2025-07-16 07:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-04 02:02
Publish the Manuscript Online	2025-08-07 06:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	From gut microbial ecology to lipid homeostasis: Decoding the role of gut microbiota in dyslipidemia pathogenesis and intervention
Manuscript Source	Invited Manuscript
All Author List	Jing Lv, He-Ping Zhao, Yan Yu, Ji-Han Wang, Xiao-Jun Zhang, Zhi-Qi Guo, Wen-Yan Jiang, Kai Wang and Lei Guo
Funding Agency and Grant Number	Funding Agency Grant Number Shaanxi Natural Science Foundation of China 2025JC-YBMS-916 Xi’an Municipal Health Commission of China 2023ms11
Corresponding Author	Lei Guo, MD, Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, No. 555 Youyi East Road, Xi’an 710054, Shaanxi Province, China. guolei0711@163.com
Key Words	Dyslipidemia; Lipid metabolism; Gut microbiota; Dietary patterns; Circadian rhythms; Probiotics; Prebiotics; Fecal microbiota transplantation
Core Tip	Dyslipidemia’s multifactorial pathogenesis involves gene-environment-microbiota crosstalk, with gut microbiota (GM) emerging as a master regulator of lipid homeostasis through lipopolysaccharide-induced very low-density lipoprotein overproduction, short-chain fatty acid-G protein-coupled receptor signaling, bile acid-farnesoid X receptor/Takeda G protein-coupled receptor 5 axis modulation, and microbiota-host non-coding RNA crosstalk. This review delineates GM-dyslipidemia interactions, molecular mechanisms, and interventions such as probiotics, prebiotics and fecal microbiota transplantation. Key challenges involve establishing causal GM-lipid pathway links and optimal intervention timing. Advancing precision therapies require longitudinal multi-omics integration coupled with gnotobiotic validation models, ultimately enabling machine learning-driven prediction of personalized microbial signatures for targeted cardiovascular prevention.
Publish Date	2025-08-07 06:39
Citation	<p>Lv J, Zhao HP, Yu Y, Wang JH, Zhang XJ, Guo ZQ, Jiang WY, Wang K, Guo L. From gut microbial ecology to lipid homeostasis: Decoding the role of gut microbiota in dyslipidemia pathogenesis and intervention. <i>World J Gastroenterol</i> 2025; 31(30): 108680</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i30/108680.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i30.108680

Full Article (PDF)	WJG-31-108680-with-cover.pdf
Manuscript File	108680_Auto_Edited_073244.docx
Answering Reviewers	108680-answering-reviewers.pdf
Audio Core Tip	108680-audio.mp3
Conflict-of-Interest Disclosure Form	108680-conflict-of-interest-statement.pdf
Copyright License Agreement	108680-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	108680-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	108680-non-native-speakers.pdf
Peer-review Report	108680-peer-reviews.pdf
Scientific Misconduct Check	108680-scientific-misconduct-check.png
Scientific Editor Work List	108680-scientific-editor-work-list.pdf
CrossCheck Report	108680-crosscheck-report.pdf