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8/7/2025 7:39:35 AM | Browse: 308 | Download: 525
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Received |
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2025-05-06 11:18 |
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Peer-Review Started |
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2025-05-06 11:18 |
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First Decision by Editorial Office Director |
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2025-05-22 15:53 |
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2025-05-22 15:53 |
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Revised |
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2025-06-16 00:53 |
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Second Decision by Editor |
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2025-07-16 02:36 |
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Final Decision by Editorial Office Director |
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2025-07-16 07:37 |
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Articles in Press |
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2025-07-16 07:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-04 02:02 |
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Publish the Manuscript Online |
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2025-08-07 06:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
From gut microbial ecology to lipid homeostasis: Decoding the role of gut microbiota in dyslipidemia pathogenesis and intervention
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jing Lv, He-Ping Zhao, Yan Yu, Ji-Han Wang, Xiao-Jun Zhang, Zhi-Qi Guo, Wen-Yan Jiang, Kai Wang and Lei Guo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shaanxi Natural Science Foundation of China |
2025JC-YBMS-916 |
| Xi’an Municipal Health Commission of China |
2023ms11 |
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| Corresponding Author |
Lei Guo, MD, Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, No. 555 Youyi East Road, Xi’an 710054, Shaanxi Province, China. guolei0711@163.com |
| Key Words |
Dyslipidemia; Lipid metabolism; Gut microbiota; Dietary patterns; Circadian rhythms; Probiotics; Prebiotics; Fecal microbiota transplantation |
| Core Tip |
Dyslipidemia’s multifactorial pathogenesis involves gene-environment-microbiota crosstalk, with gut microbiota (GM) emerging as a master regulator of lipid homeostasis through lipopolysaccharide-induced very low-density lipoprotein overproduction, short-chain fatty acid-G protein-coupled receptor signaling, bile acid-farnesoid X receptor/Takeda G protein-coupled receptor 5 axis modulation, and microbiota-host non-coding RNA crosstalk. This review delineates GM-dyslipidemia interactions, molecular mechanisms, and interventions such as probiotics, prebiotics and fecal microbiota transplantation. Key challenges involve establishing causal GM-lipid pathway links and optimal intervention timing. Advancing precision therapies require longitudinal multi-omics integration coupled with gnotobiotic validation models, ultimately enabling machine learning-driven prediction of personalized microbial signatures for targeted cardiovascular prevention. |
| Publish Date |
2025-08-07 06:39 |
| Citation |
Lv J, Zhao HP, Yu Y, Wang JH, Zhang XJ, Guo ZQ, Jiang WY, Wang K, Guo L. From gut microbial ecology to lipid homeostasis: Decoding the role of gut microbiota in dyslipidemia pathogenesis and intervention. World J Gastroenterol 2025; 31(30): 108680 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i30/108680.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i30.108680 |
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