Publication Name	World Journal of Cardiology
Manuscript ID	108749
Country	Italy

Received	2025-04-22 13:24
Peer-Review Started	2025-04-22 13:24
To Make the First Decision
Return for Revision	2025-05-12 10:10
Revised	2025-05-25 15:57
Second Decision	2025-07-18 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-18 06:22
Articles in Press	2025-07-18 06:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-11 09:09
Publish the Manuscript Online	2025-08-21 08:16

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Is metabolically healthy obesity shaped by inflammation, gender differences, and fat distribution?
Manuscript Source	Invited Manuscript
All Author List	Davide Ramoni, Luca Liberale, Federico Carbone and Fabrizio Montecucco
Funding Agency and Grant Number
Corresponding Author	Fabrizio Montecucco, MD, PhD, Professor, Department of Internal Medicine, University of Genoa, ., Viale Benedetto XV 6, Genoa 16132, Italy. fabrizio.montecucco@unige.it
Key Words	Cardiovascular risk; Epicardial adipose tissue; Inflammation; Metabolically healthy obesity; Metaflammation; Obesity; Sex differences; Visceral fat
Core Tip	Obesity is not a uniform condition but comprises multiple phnotypes with distinct cardiovascular (CV) risks. The concept of metabolically healthy obesity is increasingly challenged by evidence of low-grade inflammation, ectopic fat accumulation, and adipose dysfunction. Inflammation, particularly in visceral and epicardial fat, plays a central role in driving subclinical CV damage, even in the absence of overt metabolic disease. Postmenopausal women are especially vulnerable due to hormonal shifts and fat redistribution. Integrating fat phenotype, inflammatory biomarkers, and sex-specific factors is essential for precise cardiometabolic risk management and targeted prevention, moving beyond body mass index-based assessments.
Publish Date	2025-08-21 08:16
Citation	<p>Ramoni D, Liberale L, Carbone F, Montecucco F. Is metabolically healthy obesity shaped by inflammation, gender differences, and fat distribution? <i>World J Cardiol</i> 2025; 17(8): 108749</p>
URL	https://www.wjgnet.com/1949-8462/full/v17/i8/108749.htm
DOI	https://dx.doi.org/10.4330/wjc.v17.i8.108749

Full Article (PDF)	WJC-17-108749-with-cover.pdf
Manuscript File	108749_Auto_Edited_074639.docx
Answering Reviewers	108749-answering-reviewers.pdf
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Scientific Editor Work List	108749-scientific-editor-work-list.pdf
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