| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Public, Environmental & Occupational Health |
| Manuscript Type |
Review |
| Article Title |
Toxins to treatments: Impact of environmental pollutants, gut microbiota, and natural compounds on non-alcoholic fatty liver disease progression
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Tanvi Sharma, Naveen Kaushal and Roobee Garla |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| DHR Women Scientist Fellowship |
12013/53/2024 |
|
| Corresponding Author |
Roobee Garla, PhD, Post Doctoral Researcher, Department of Biophysics, Panjab University, Department of Biophysics, Panjab University, Chandigarh, 160014, India. rubygarla@yahoo.co.in., CHANDIGARH 160014, CHANDIGARH, India. rubygarla@yahoo.co.in |
| Key Words |
Non-alcoholic fatty liver disease; Gut microbiome; Environmental pollutant; Selenium; Short-chain fatty acids |
| Core Tip |
A combination of factors, such as nutrition, oxidative stress, inflammation, gut dysbiosis, and heredity, causes a complicated metabolic disease, NAFLD. Environmental pollutants are becoming more prominent factors in its development. In this review, we will be discussing the treatment regimens that incorporate genetic, microbiological, and metabolic characteristics that are essential. Along with lifestyle changes, new approaches like microbiota-targeted treatments and selenium supplementation show promise but require more research. To create accurate and efficient therapies for the prevention and management of NAFLD, future research should prioritize early screening, particularly in high-risk groups, and concentrate on the dynamics of the gut-liver axis. |
| Publish Date |
2025-08-27 09:21 |
| Citation |
<p>Sharma T, Kaushal N, Garla R. Toxins to treatments: Impact of environmental pollutants, gut microbiota, and natural compounds on non-alcoholic fatty liver disease progression. <i>World J Hepatol</i> 2025; 17(8): 108772</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i8/108772.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i8.108772 |
