Publication Name	World Journal of Gastroenterology
Manuscript ID	108815
Country	China

Received	2025-04-27 15:09
Peer-Review Started	2025-04-27 15:09
To Make the First Decision
Return for Revision	2025-05-01 02:08
Revised	2025-05-10 04:53
Second Decision	2025-05-26 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-26 05:43
Articles in Press	2025-05-26 05:43
Publication Fee Transferred	2025-05-12 08:06
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-07 01:06
Publish the Manuscript Online	2025-06-12 03:45

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Intermittent fasting exacerbates colon inflammation by promoting Th17 cell differentiation through inhibition of gut microbiota-derived indoleacrylic acid
Manuscript Source	Unsolicited Manuscript
All Author List	Rui Fu, Peng Zhang, Jia-Wei Zhang, Yuan Hong, Bo Chen and Guo-Dong Cao
Funding Agency and Grant Number	Funding Agency Grant Number Anhui University Research Project No. 2022AH051171 Natural Science Foundation Project of Anhui Province No. 2408085QH271 Anhui Medical University Scientific Research Level Improvement Plan No. 2022xkjT028 Health Research Project of Anhui Province No. AHWJ2023A30047 Anhui Provincial Natural Science Foundation No. 2208085MH240 Scientific Research Project of Anhui Provincial Department of Education No. 2022AH051167 Anhui Quality Engineering Project No. 2023sx200 Anhui Quality Engineering Project No. 2023jyjxggyjY087 Anhui Quality Engineering Project No. 2023zyxwjxalk046 Anhui Provincial Postgraduate Education Quality Project No. 2024cxcysj062 Anhui Medical University Graduate Research and Practice Innovation Project No. YJS20240095
Corresponding Author	Guo-Dong Cao, Full Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. 11718242@zju.edu.cn
Key Words	Intermittent fasting; Colon inflammation; Th17 cell; Gut microbiota; Metabolomics
Core Tip	This study demonstrates that long-term intermittent fasting (IF) compromises intestinal barrier function, alters the metabolite profile (reducing anti-inflammatory compounds and increasing pro-inflammatory ones), and induces dysbiosis (increasing pathogenic bacteria while decreasing short-chain fatty acid-producing bacteria), which collectively promote Th17-driven inflammation. Exogenous indoleacrylic acid supplementation restores barrier integrity, suppresses Th17 activation, and enhances interleukin-10 expression, highlighting its therapeutic promise and emphasizing the need for a reevaluation of the long-term safety of IF due to its potential gut-disrupting effects.
Publish Date	2025-06-12 03:45
Citation	<p>Fu R, Zhang P, Zhang JW, Hong Y, Chen B, Cao GD. Intermittent fasting exacerbates colon inflammation by promoting Th17 cell differentiation through inhibition of gut microbiota-derived indoleacrylic acid. <i>World J Gastroenterol</i> 2025; 31(22): 108815</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i22/108815.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i22.108815

Full Article (PDF)	WJG-31-108815-with-cover.pdf
The ARRIVE Guidelines	108815-The-ARRIVE-Guidelines.pdf
Manuscript File	108815_Auto_Edited_061044.docx
Answering Reviewers	108815-answering-reviewers.pdf
Audio Core Tip	108815-audio.mp3
Biostatistics Review Certificate	108815-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	108815-conflict-of-interest-statement.pdf
Copyright License Agreement	108815-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	108815-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	108815-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	108815-non-native-speakers.pdf
Peer-review Report	108815-peer-reviews.pdf
Scientific Misconduct Check	108815-scientific-misconduct-check.png
Scientific Editor Work List	108815-scientific-editor-work-list.pdf
CrossCheck Report	108815-crosscheck-report.pdf