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9/1/2025 9:09:41 AM | Browse: 197 | Download: 158
Publication Name World Journal of Gastroenterology
Manuscript ID 108872
Country France
Received
2025-04-30 03:45
Peer-Review Started
2025-04-30 03:45
To Make the First Decision
Return for Revision
2025-05-30 18:28
Revised
2025-06-27 15:07
Second Decision
2025-08-11 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-08-12 10:09
Articles in Press
2025-08-12 10:09
Publication Fee Transferred
2025-06-30 13:43
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-08-25 00:43
Publish the Manuscript Online
2025-09-01 08:05
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Methotrexate in the management of Crohn’s disease: A practice survey of gastroenterologists in France
Manuscript Source Unsolicited Manuscript
All Author List Guillaume Bonnaud, Jennifer Becker, Myriam Chebbah, Agnès Courbeyrette and Patrick Faure
Funding Agency and Grant Number
Corresponding Author Patrick Faure, Hépato-Gastro-Entérologie, Clinique Pasteur, 45 Av. de Lombez BP, Toulouse 31076, France. pfaure@clinique-pasteur.com
Key Words Methotrexate; Crohn’s disease; Combination therapy; Immunosuppressant; Azathioprine; Guidelines; France; Practice survey; Real-world evidence
Core Tip This practice survey among French gastroenterologists reveals a growing confidence in methotrexate (MTX) for managing Crohn’s disease (CD), particularly in combination with biologics for specific patient profiles such as those with joint involvement or Epstein-Barr virus negativity. While MTX is often underutilized compared to azathioprine, respondents acknowledged its favorable long-term safety profile. The study highlights variability in prescribing habits and underlines the need for clearer clinical guidelines and more real-world evidence to support optimal use of MTX in CD.
Publish Date 2025-09-01 08:05
Citation <p>Bonnaud G, Becker J, Chebbah M, Courbeyrette A, Faure P. Methotrexate in the management of Crohn’s disease: A practice survey of gastroenterologists in France. <i>World J Gastroenterol</i> 2025; 31(33): 108872</p>
URL https://www.wjgnet.com/1007-9327/full/v31/i33/108872.htm
DOI https://dx.doi.org/10.3748/wjg.v31.i33.108872
Full Article (PDF) WJG-31-108872-with-cover.pdf
STROBE Statement 108872-STROBE-statement.pdf
Manuscript File 108872_Auto_Edited_011334.docx
Answering Reviewers 108872-answering-reviewers.pdf
Audio Core Tip 108872-audio.mp3
Biostatistics Review Certificate 108872-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 108872-conflict-of-interest-statement.pdf
Copyright License Agreement 108872-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 108872-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 108872-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 108872-non-native-speakers.pdf
Supplementary Material 108872-supplementary-material.pdf
Peer-review Report 108872-peer-reviews.pdf
Scientific Misconduct Check 108872-scientific-misconduct-check.png
Scientific Editor Work List 108872-scientific-editor-work-list.pdf
CrossCheck Report 108872-crosscheck-report.pdf