| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Stem cell-derived neural organoids as platforms to investigate glioblastoma invasion and migration: A systematic review
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Arielly da Hora Alves, Nicole Mastandrea Ennes do Valle, Bruno Yukio Yokota-Moreno, Marta Caetano dos Santos Galanciak, Keithy Felix da Silva, Javier Bustamante Mamani, Andrea Laurato Sertie, Fernando Anselmo de Oliveira, Mariana Penteado Nucci and Lionel Fernel Gamarra |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Conselho Nacional de Desenvolvimento Científico e Tecnológico |
307318/2023-0, 102035/2024-5 |
| Fundação de Amparo à Pesquisa do Estado de São Paulo |
2023/10843-7, 2019/21070-3 |
| Nanotechnology National Laboratory System 2.0, Ministry of Science, Technology, Innovation and Communication |
442539/2019-3 |
|
| Corresponding Author |
Lionel Fernel Gamarra, Full Professor, PhD, Instituto Israelita de Ensino e Pesquisa, Hospital Albert Einstein, Avenue Albert Einstein 640, São Paulo 05652-900, Brazil. lionelgamarra7@gmail.com |
| Key Words |
Glioblastoma; Stem cell; Organoid; Spheroid; Invasion; Migration |
| Core Tip |
This systematic review highlights human stem cell-derived neural organoids as promising three-dimensional models for investigating glioblastoma stem cell invasion/migration. Despite considerable methodological heterogeneity, the studies demonstrate the potential of these models to replicate key aspects of the tumor microenvironment, assess therapeutic responses, and support personalized medicine approaches. However, the lack of standardized protocols and evaluation methods poses a challenge to reproducibility and broader translational use. Standardizing methodologies will be key to advancing these models and establishing their value in translational glioblastoma research and the development of targeted therapies. |
| Publish Date |
2025-08-21 05:29 |
| Citation |
<p>Alves ADH, Ennes do Valle NM, Yokota-Moreno BY, Galanciak MCDS, Felix da Silva K, Mamani JB, Sertie AL, de Oliveira FA, Nucci MP, Gamarra LF. Stem cell-derived neural organoids as platforms to investigate glioblastoma invasion and migration: A systematic review. <i>World J Stem Cells</i> 2025; 17(8): 108898</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i8/108898.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i8.108898 |
