| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Methionyl-tRNA synthetase 1 participates in hepatocellular carcinoma and its regulated gene profile possesses potent prognostic ability
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-Yan Bu, Hong Huang, Jia Li, Ze-Bing Huang, Yan Huang, Yu-Kun Huang, Ai-Min Wang, Li Wu, Jiao Yuan, Rong-Jun Wang, Min Lu, Song-Man Yu, Pan-Pan Yi, Ya-Yu Chen, Yu-Peng Jiang and Xing-Wang Hu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82300694 |
| National Natural Science Foundation of China |
81970523 |
| Natural Science Foundation of Hunan Province |
2022JJ70165 |
| Natural Science Foundation of Hunan Province |
2021JJ31067 |
| Natural Science Foundation of Hunan Province |
2023JJ40828 |
| Natural Science Foundation of Hunan Province |
2022JJ40704 |
|
| Corresponding Author |
Xing-Wang Hu, Department of Infectious Diseases, Hunan Key Laboratory of Viral Hepatitis, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87th of Xiangya Road, Changsha, Hunan, China, Changsha 410008, Hunan Province, China. lebithu@csu.edu.cn |
| Key Words |
Methionyl-tRNA synthetase 1; Hepatocellular carcinoma; Aminoacyl-tRNA synthetases; Prognostic model; Bioinformatics |
| Core Tip |
Aminoacyl-tRNA synthetases (ARSs) are important regulators implicated in the occurrence and progression of several cancers. However, their specific function in hepatocellular carcinoma (HCC) remains unclear, and effective ARSs-related prognostic risk factors for stratifying patients are lacking. In this study, we identified that Methionyl-tRNA synthetase 1 (MARS1) promotes the proliferation, migration, invasion, and tumor formation of hepatoma cells in vitro and in vivo, highlighting its potential as a therapeutic target for HCC. Moreover, we established MARS1-related prognostic score as an independent prognostic factor for patient survival and a predictor of tumor treatment response, contributing valuable insights into the development of personalized treatment strategies. |
| Publish Date |
2025-09-15 08:37 |
| Citation |
<p>Bu HY, Huang H, Li J, Huang ZB, Huang Y, Huang YK, Wang AM, Wu L, Yuan J, Wang RJ, Lu M, Yu SM, Yi PP, Chen YY, Jiang YP, Hu XW. Methionyl-tRNA synthetase 1 participates in hepatocellular carcinoma and its regulated gene profile possesses potent prognostic ability. <i>World J Gastrointest Oncol</i> 2025; 17(9): 109127</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i9/109127.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i9.109127 |
