Publication Name	World Journal of Virology
Manuscript ID	109170
Country	India

Received	2025-05-06 03:59
Peer-Review Started	2025-05-06 04:02
To Make the First Decision
Return for Revision	2025-05-17 15:26
Revised	2025-05-28 18:08
Second Decision	2025-09-01 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-01 08:53
Articles in Press	2025-09-01 08:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-11 01:58
Publish the Manuscript Online	2025-09-25 09:22

ISSN	2220-3249 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Virology
Manuscript Type	Retrospective Study
Article Title	Pre-hospital proton pump inhibitor use and clinical outcomes in hospitalized COVID-19 patients: A retrospective case-control study
Manuscript Source	Invited Manuscript
All Author List	Harinivaas Shanmugavel Geetha, Sushmita Prabhu, Mithil Gowda Suresh, George M Abraham, Akshaya Sekar, Safia Mohamed, Abinesh Sekar, Juniali Hatwal, Aalam Sohal and Akash Batta
Funding Agency and Grant Number
Corresponding Author	Akash Batta, Associate Professor, Department of Cardiology, Dayanand Medical College and Hospital, Tagore Nagar, Civil Lines, Ludhiana 141001, Punjab, India. akashbatta02@gmail.com
Key Words	Comorbidities; Case-control study; mortality; Intensive care unit; Proton pump inhibitors; SARS-CoV-2; COVID-19
Core Tip	This retrospective case-control study investigated the association between pre-hospital proton pump inhibitor (PPI) use and outcomes among patients hospitalized with coronavirus disease 2019 (COVID-19). After adjusting for multiple confounders, pre-hospital PPI use was associated with a lower risk of intensive care unit admission and in-hospital mortality. While the underlying mechanisms remain unclear, the findings suggest that chronic PPI use may not be associated with adverse COVID-19 outcomes.
Publish Date	2025-09-25 09:22
Citation	<p>Shanmugavel Geetha H, Prabhu S, Suresh MG, Abraham GM, Sekar A, Mohamed S, Sekar A, Hatwal J, Sohal A, Batta A. Pre-hospital proton pump inhibitor use and clinical outcomes in hospitalized COVID-19 patients: A retrospective case-control study. <i>World J Virol</i> 2025; 14(3): 109170</p>
URL	https://www.wjgnet.com/2220-3249/full/v14/i3/109170.htm
DOI	https://dx.doi.org/10.5501/wjv.v14.i3.109170

Full Article (PDF)	WJV-14-109170-with-cover.pdf
Manuscript File	109170_Auto_Edited_091245.docx
Answering Reviewers	109170-answering-reviewers.pdf
Audio Core Tip	109170-audio.m4a
Biostatistics Review Certificate	109170-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	109170-conflict-of-interest-statement.pdf
Copyright License Agreement	109170-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	109170-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	109170-institutional-review-board-statement.pdf
Peer-review Report	109170-peer-reviews.pdf
Scientific Misconduct Check	109170-scientific-misconduct-check.png
Scientific Editor Work List	109170-scientific-editor-work-list.pdf
CrossCheck Report	109170-crosscheck-report.pdf