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10/24/2025 10:30:17 AM | Browse: 29 | Download: 51
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Received |
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2025-05-06 04:04 |
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Peer-Review Started |
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2025-05-06 04:04 |
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To Make the First Decision |
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Return for Revision |
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2025-05-28 09:46 |
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2025-06-05 19:55 |
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Second Decision |
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2025-09-09 02:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-10 07:40 |
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Articles in Press |
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2025-09-10 07:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-17 00:22 |
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Publish the Manuscript Online |
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2025-10-24 09:58 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Heart-brain axis, gliotransmitters and peripheral neurogenesis: Emerging regenerative roles of cardiac nexus glia in health and disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Abirami Sekhar and Mahesh Kandasamy |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| UGC-FRP |
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| Rashtriya Uchchatar Shiksha Abhiyan (RUSA) 2.0, Biological Sciences, Bharathidasan University |
TN RUSA: 311/RUSA (2.0)/2018 |
| Anusandhan National Research Foundation (ANRF)/Science Engineering Research Board (SERB) |
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| UGC-SAP and DST-FIST |
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| Corresponding Author |
Mahesh Kandasamy, Assistant Professor, Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli – 620024, Tamilnadu, India., Tiruchirappalli 620024, Tamil Nadu, India. mahesh.kandasamy@bdu.ac.in |
| Key Words |
Heart-brain-axis; Cardiac nexus glia; Neuroplasticity; Astrocytes; Gliotransmitters; Neuroregeneration |
| Core Tip |
Cardiac nexus cells are a specialized cell type in the heart that exhibit phenotypic similarities to astrocytes in the brain. As radial glia-like astrocytes serve as multipotent neural stem cells, cardiac nexus cells may differentiate into neurons, astrocytes, and oligodendrocytes. This article introduces a novel concept of peripheral neurogenesis, proposing that neurogenic activity originates outside the central nervous system, especially in the heart. Eventually, cardiac nexus cells could contribute to the neurocardiac axis through the release of gliotransmitters and regulate neurogenesis in the brain, while their dysfunction could be associated with neurocardiac disorders. |
| Publish Date |
2025-10-24 09:58 |
| Citation |
<p>Sekhar A, Kandasamy M. Heart-brain axis, gliotransmitters and peripheral neurogenesis: Emerging regenerative roles of cardiac nexus glia in health and disease. <i>World J Cardiol</i> 2025; 17(10): 109174</p> |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i10/109174.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i10.109174 |
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