Publication Name	World Journal of Gastroenterology
Manuscript ID	109187
Country	China

Received	2025-05-06 07:33
Peer-Review Started	2025-05-06 07:34
To Make the First Decision
Return for Revision	2025-05-22 15:50
Revised	2025-06-09 11:45
Second Decision	2025-07-21 02:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-21 07:11
Articles in Press	2025-07-21 07:11
Publication Fee Transferred	2025-06-10 13:37
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-04 01:21
Publish the Manuscript Online	2025-08-07 06:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Unveiling Xuanshen decoction: A novel approach to combat slow transit constipation
Manuscript Source	Unsolicited Manuscript
All Author List	Xing-Lin Zeng, Lian-Jun Zhu, Yu Zhang, Xiang-Dong Yang and Yu-Jun Zhu
Funding Agency and Grant Number	Funding Agency Grant Number 2024 Hospital Innovation Talent Cultivation Fund Project No. 2024YGKT12
Corresponding Author	Yu-Jun Zhu, Associate Chief Physician, MD, Department of General Surgery, Jiangbei Campus of The First Affiliated Hospital of Army Medical University, No. 29 Jianxin East Road, Jiangbei District, Chongqing 400020, China. merezyj@163.com
Key Words	Molecular docking; Experimental verification; Network pharmacology; Oxidative stress; Slow transit constipation
Core Tip	There are limited drugs available to treat slow transit constipation (STC). Xuanshen decoction is a traditional Chinese medicine formulation that can effectively treat STC. In this study, Xuanshen decoction significantly alleviated the symptoms of STC in rats. Xuanshen decoction promoted the expression of key proteins in the phosphoinositide 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 signaling pathway, improved oxidative stress-related parameters, and suppressed the apoptosis of interstitial cells of Cajal.
Publish Date	2025-08-07 06:39
Citation	<p>Zeng XL, Zhu LJ, Zhang Y, Yang XD, Zhu YJ. Unveiling Xuanshen decoction: A novel approach to combat slow transit constipation. <i>World J Gastroenterol</i> 2025; 31(30): 109187</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i30/109187.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i30.109187

Full Article (PDF)	WJG-31-109187-with-cover.pdf
The ARRIVE Guidelines	109187-The-ARRIVE-Guidelines.pdf
Manuscript File	109187_Auto_Edited_010201.docx
Answering Reviewers	109187-answering-reviewers.pdf
Audio Core Tip	109187-audio.wav
Biostatistics Review Certificate	109187-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	109187-conflict-of-interest-statement.pdf
Copyright License Agreement	109187-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	109187-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	109187-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	109187-non-native-speakers.pdf
Supplementary Material	109187-supplementary-material.pdf
Peer-review Report	109187-peer-reviews.pdf
Scientific Misconduct Check	109187-scientific-misconduct-check.png
Scientific Editor Work List	109187-scientific-editor-work-list.pdf
CrossCheck Report	109187-crosscheck-report.pdf