Publication Name	World Journal of Clinical Cases
Manuscript ID	109212
Country	United States

Received	2025-05-06 00:38
Peer-Review Started	2025-05-06 00:38
To Make the First Decision
Return for Revision	2025-05-17 07:58
Revised	2025-05-25 23:26
Second Decision	2025-08-12 02:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-12 10:24
Articles in Press	2025-08-12 10:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-15 07:02
Publish the Manuscript Online	2025-10-11 09:30

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Body mass index and its association with clinical outcomes in acute liver failure
Manuscript Source	Invited Manuscript
All Author List	Arunkumar Krishnan, Sameer Khan, Julia Gips, Saleh A Alqahtani, Dhananjay Vaidya, Yi-Si Liu, Ahyoung Kim, Amanda Su, Ahmet Gurakar, James P Hamilton and Tinsay A Woreta
Funding Agency and Grant Number
Corresponding Author
Key Words	Acute liver failure; Body mass index; Obesity; Hepatic encephalopathy; Organ failure; Liver transplantation; Survival; Mortality; Outcome
Core Tip	The most common causes of acute liver failure (ALF) were acetaminophen toxicity, drug-related hepatitis, and other etiologies. Patients who underwent liver transplantation (LT) or died were older, had a higher body mass index (BMI), and were more likely to have higher-grade hepatic encephalopathy and cerebral edema. They also had higher levels of lactate and phosphate. Overweight and obese patients with ALF had a higher risk of mortality or the need for LT than normal-weight patients. Factors such as increasing age, other etiologies of ALF, higher BMI, and abnormal laboratory values were associated with an increased risk of poor outcomes in ALF patients.
Publish Date	2025-10-11 09:30
Citation	<p>Krishnan A, Khan S, Gips J, Alqahtani SA, Vaidya D, Liu YS, Kim A, Su A, Gurakar A, Hamilton JP, Woreta TA. Body mass index and its association with clinical outcomes in acute liver failure. <i>World J Clin Cases</i> 2025; 13(30): 109212</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i30/109212.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i30.109212

Full Article (PDF)	WJCC-13-109212-with-cover.pdf
STROBE Statement	109212-STROBE-statement.pdf
Manuscript File	109212_Auto_Edited_013322.docx
Answering Reviewers	109212-answering-reviewers.pdf
Audio Core Tip	109212-audio.mp3
Biostatistics Review Certificate	109212-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	109212-conflict-of-interest-statement.pdf
Copyright License Agreement	109212-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	109212-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	109212-institutional-review-board-statement.pdf
Supplementary Material	109212-supplementary-material.pdf
Peer-review Report	109212-peer-reviews.pdf
Scientific Misconduct Check	109212-scientific-misconduct-check.png
Scientific Editor Work List	109212-scientific-editor-work-list.pdf
CrossCheck Report	109212-crosscheck-report.pdf