| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Observational Study |
| Article Title |
Cardiopulmonary changes and its association with clinical features in noncirrhotic portal hypertension
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Harish Gopalakrishna, My-Le Nguyen, Maria Mironova, Gracia M Viana Rodriguez, Rownock Afruza, Moumita Chakraborty, Matt G Menkart, Jenna L Oringher, Shani Scott, Gayatri B Nair, David E Kleiner, Christopher Koh, Michael Fallon, Vandana Sachdev and Theo Heller |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Division of Intramural Research Program at National Institute of Diabetes and Digestive and Kidney Diseases |
1ZIADK075008 |
|
| Corresponding Author |
Harish Gopalakrishna, MD, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive BLDG, Bethesda, MD 20892, United States. hkgp44@gmail.com |
| Key Words |
Cardiomyopathy; Hepatopulmonary syndrome; Portopulmonary hypertension; Porto-sinusoidal vascular disease; Echocardiography; Nodular regenerative hyperplasia; Intrapulmonary vascular dilatation; Bile acids; Angiopoietin 2; Vascular cell adhesion molecule 1 |
| Core Tip |
In this study, Cardiopulmonary changes in noncirrhotic portal hypertension (NCPH) were investigated using echocardiography and its association with clinical features was explored. Cardiopulmonary changes are prevalent in NCPH patients as in those with cirrhosis. Unlike cirrhosis, cardiopulmonary complications occur despite preserved synthetic function of liver. Liver stiffness measurement and aspartate aminotransferase to alanine aminotransferase ratio help identify patients at risk of hepatopulmonary syndrome. |
| Publish Date |
2025-08-07 06:39 |
| Citation |
<p>Gopalakrishna H, Nguyen ML, Mironova M, Viana Rodriguez GM, Afruza R, Chakraborty M, Menkart MG, Oringher JL, Scott S, Nair GB, Kleiner DE, Koh C, Fallon M, Sachdev V, Heller T. Cardiopulmonary changes and its association with clinical features in noncirrhotic portal hypertension. <i>World J Gastroenterol</i> 2025; 31(30): 109256</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i30/109256.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i30.109256 |
