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9/11/2025 9:45:46 AM | Browse: 221 | Download: 63
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Received |
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2025-05-07 14:03 |
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2025-05-09 07:12 |
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2025-05-15 06:39 |
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2025-06-02 05:10 |
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Second Decision |
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2025-07-31 02:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-31 08:19 |
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Articles in Press |
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2025-07-31 08:19 |
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Typeset the Manuscript |
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2025-09-03 01:10 |
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Publish the Manuscript Online |
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2025-09-11 09:41 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Editorial |
| Article Title |
β-cell dedifferentiation in type 2 diabetes: Interplay of metabolic stress, endoplasmic reticulum dysfunction, and forkhead box protein O1 inhibition
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ashraf Al Madhoun, Fatemah Bahman and Rasheed Ahmad |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Kuwait Foundation for the Advancement of Sciences |
RACB-2021-007 |
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| Corresponding Author |
Ashraf Al Madhoun, Senior Scientist, Department of Translational Medicine, Dasman Diabetes Institute, Jassim AlBahar Street, Dasman 15400, Kuwait. ashraf.madhoun@dasmaninstitute.org |
| Key Words |
Diabetes; Pancreatic β-cells; Dedifferentiation; Endoplasmic reticulum stress; Forkhead box protein O1; Aldehyde dehydrogenase 1 family member A3 |
| Core Tip |
This editorial highlights the emerging role of β-cell dedifferentiation as a central mechanism of β-cell failure in type 2 diabetes, alongside apoptosis. We emphasize recent findings that chronic metabolic stressors, namely glucotoxicity and lipotoxicity, initiate ER stress and suppress forkhead box protein O1 activity, leading to the loss of β-cell identity and function. The reversibility of this process introduces new therapeutic possibilities aimed at preserving or restoring endogenous insulin production. |
| Publish Date |
2025-09-11 09:41 |
| Citation |
<p>Al Madhoun A, Bahman F, Ahmad R. β-cell dedifferentiation in type 2 diabetes: Interplay of metabolic stress, endoplasmic reticulum dysfunction, and forkhead box protein O1 inhibition. <i>World J Diabetes</i> 2025; 16(9): 109274</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i9/109274.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i9.109274 |
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