| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Prospective Study |
| Article Title |
Role of preoperative circulating tumor DNA in predicting occult metastases in resectable and borderline resectable pancreatic ductal adenocarcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Takeshi Murakami, Masafumi Imamura, Yasutoshi Kimura, Kazunori Watanabe, Yoshihito Shinohara, Toru Nakamura, Siew-Kee Low, Masayo Motoya, Yujiro Kawakami, Yoshiharu Masaki, Tomohiro Kubo, Makoto Yoshida, Eiji Yoshida, Toru Kato, Kazuharu Kukita, Daisuke Kyuno and Ichiro Takemasa |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Council for Science, Technology, and Innovation (CSTI) Cross-Ministerial Strategic Innovation Promotion Program (SIP) “Innovative AI Hospital System” (National Institute of Biomedical Innovation, Health and Nutrition) |
No. SIPAIH18C03 |
| Japan Society for the Promotion of Science (JSPS) KAKENHI |
No. JP19K09179 |
| Japan Society for the Promotion of Science (JSPS) KAKENHI |
No. JP23K08158 |
|
| Corresponding Author |
Masafumi Imamura, MD, PhD, Department of Surgery, Surgical Oncology and Science, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo 060-0061, Hokkaidō, Japan. imamura@sapmed.ac.jp |
| Key Words |
Pancreatic ductal adenocarcinoma; Occult metastases; Early recurrence; Multidisciplinary treatment; Circulating tumor DNA |
| Core Tip |
Circulating tumor DNA (ctDNA) levels, when used alongside conventional biomarkers, may offer valuable insights for developing individualized treatment strategies in pancreatic ductal adenocarcinoma. These include determining the optimal regimen and duration of neoadjuvant therapy. In addition, ctDNA may help identify the most appropriate timing for surgery, thereby enabling more precise treatment decisions and potentially contributing to improved clinical outcomes and long-term prognosis. |
| Publish Date |
2025-08-27 03:44 |
| Citation |
<p>Murakami T, Imamura M, Kimura Y, Watanabe K, Shinohara Y, Nakamura T, Low SK, Motoya M, Kawakami Y, Masaki Y, Kubo T, Yoshida M, Yoshida E, Kato T, Kukita K, Kyuno D, Takemasa I. Role of preoperative circulating tumor DNA in predicting occult metastases in resectable and borderline resectable pancreatic ductal adenocarcinoma. <i>World J Gastroenterol</i> 2025; 31(32): 109383</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i32/109383.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i32.109383 |
