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10/27/2025 11:15:07 AM | Browse: 2 | Download: 11
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Received |
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2025-05-09 08:19 |
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Peer-Review Started |
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2025-05-12 00:17 |
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To Make the First Decision |
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Return for Revision |
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2025-05-29 08:52 |
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Revised |
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2025-06-08 10:38 |
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Second Decision |
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2025-08-26 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-26 08:59 |
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Articles in Press |
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2025-08-26 08:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-30 09:11 |
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Publish the Manuscript Online |
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2025-10-27 10:57 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Mechanistic interplay between aflatoxin B1 and tissue inhibitor of metalloproteinase-3 in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yan Luo, Li-Juan Wang and Cheng-Long Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chongqing Health Commission and Science and Technology Bureau |
No. 2023MSXM060 |
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| Corresponding Author |
Cheng-Long Wang, Department of Pathology, Chongqing Traditional Chinese Medicine Hospital, No. 6 Seventh Panxi Branch Road, Jiangbei District, Chongqing 400021, China. 171909771@qq.com |
| Key Words |
Hepatocellular carcinoma; Tissue inhibitor of metalloproteinase-3; Aflatoxin B1; Prognosis; Biomarker |
| Core Tip |
This article elucidates the critical mechanistic interplay between aflatoxin B1 (AFB1) exposure and tissue inhibitor of metalloproteinase-3 (TIMP-3) dysregulation in hepatocellular carcinoma (HCC). We propose that AFB1 contributes directly to TIMP-3 downregulation, potentially via epigenetic silencing or miRNA dysregulation, thereby promoting AFB1-related HCC aggressiveness. Understanding this AFB1-TIMP-3 axis is crucial for validating TIMP-3 as a precise prognostic biomarker and a specific therapeutic target in AFB1-related HCC. Focused research is imperative in high AFB1-exposure regions to unravel these molecular interactions and develop targeted interventions aimed at restoring TIMP-3 function, ultimately improving patient outcomes. |
| Publish Date |
2025-10-27 10:57 |
| Citation |
<p>Luo Y, Wang LJ, Wang CL. Mechanistic interplay between aflatoxin B1 and tissue inhibitor of metalloproteinase-3 in hepatocellular carcinoma. <i>World J Hepatol</i> 2025; 17(10): 109391</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i10/109391.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i10.109391 |
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