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11/28/2025 5:48:51 AM | Browse: 21 | Download: 57
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Received |
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2025-05-20 07:14 |
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Peer-Review Started |
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2025-05-20 07:14 |
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To Make the First Decision |
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Return for Revision |
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2025-06-11 07:22 |
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2025-08-07 11:31 |
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Second Decision |
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2025-10-20 02:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-10-20 05:44 |
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Articles in Press |
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2025-10-20 05:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-21 01:05 |
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Publish the Manuscript Online |
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2025-11-28 03:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Review |
| Article Title |
Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lie Zheng and Sheng-Lei Duan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82574996 |
| Xi’an Science and Technology Plan Project |
23YXYJ0162 |
| Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Plan Project |
TZKN-CXRC-16 |
| Project of Shaanxi Administration of Traditional Chinese Medicine |
SZY-KJCYC-2025-JC-010 |
| Shaanxi Province Key Research and Development Plan Project-Social Development Field |
2025SF-YBXM-498 |
| The "Nursery Cultivation Plan" Project of Shaanxi Provincial Academy of Chinese Medicine and Shaanxi Provincial Hospital of Traditional Chinese Medicine for the Year 2025 |
2025-04 |
| the Fifth Batch of Outstanding Clinical Talents in Traditional Chinese Medicine Project of Shaanxi Province, Shaanxi Traditional Chinese Medicine Letter[2025] |
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| Corresponding Author |
Sheng-Lei Duan, Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, No. 4 Xihuamen Street, Lianhu District, Xi’an 710003, Shaanxi Province, China. 281930369@qq.com |
| Key Words |
Intestinal macrophages; Enteric nervous system; Inflammatory bowel disease; Vagus nerve stimulation; Cholinergic pathway |
| Core Tip |
Macrophages are a special type of phagocytes that play a crucial role in maintaining intestinal homeostasis and movement. In the intestinal tract, Mφ is classified into different subgroups based on its position in the parietal layer and is closely related to the microenvironment. The current research focus is on developing non-invasive vagus nerve stimulation (VNS) technology to provide a safer and more tolerable treatment option for inflammatory bowel disease (IBD). Although preliminary data suggest that percutaneous VNS treatment for IBD may be effective, further research is needed to better prove the evidence of VNS treatment for chronic inflammatory diseases. |
| Publish Date |
2025-11-28 03:10 |
| Citation |
<p>Zheng L, Duan SL. Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway. <i>World J Gastroenterol</i> 2025; 31(44): 109440</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i44/109440.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i44.109440 |
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