Publication Name	World Journal of Gastroenterology
Manuscript ID	109585
Country	China

Received	2025-05-16 07:47
Peer-Review Started	2025-05-16 07:47
To Make the First Decision
Return for Revision	2025-05-26 20:36
Revised	2025-06-08 16:10
Second Decision	2025-07-02 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-02 05:39
Articles in Press	2025-07-02 05:39
Publication Fee Transferred	2025-06-12 10:31
Edit the Manuscript by Language Editor	2025-07-20 17:52
Typeset the Manuscript	2025-08-04 01:36
Publish the Manuscript Online	2025-08-07 06:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Factors influencing diagnostic delays in celiac disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ting Li, Yan Feng, Man Wang, Chun Wang and Feng Gao
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of the Xinjiang Autonomous Region 2023D01C76 Central Government Guide Local Science and Technology Development Special Fund Project ZYYD2024JD1
Corresponding Author	Feng Gao, Chief Physician, PhD, Department of Gastroenterology, People’s Hospital of Xinjiang Uygur Autonomous Region, 91 Tianchi Road, Urumqi, Xinjiang, China, Urumqi 830001, China. xjgf0991@163.com
Key Words	Celiac disease; Delayed diagnosis; Restricted cubic splines; Independent risk factors; Blood urea nitrogen
Core Tip	This study presents the largest single-center cohort of Chinese celiac disease (CeD) patients (Marsh ≥ II histopathology) leveraging Xinjiang’s regional referral advantage. Among 166 CeD patients, 42.2% experienced diagnostic delay (> 2 years). Blood urea nitrogen (BUN) was identified as an independent risk factor (OR = 1.29), with risk significantly increasing at ≥ 4.3 mmol/L. Subgroup analyses showed stronger associations of BUN with diagnostic delay in females, patients with non-classical CeD phenotypes, Kazak individuals, and other subgroups. These findings highlight BUN as a novel predictor and provide evidence to prioritize high-risk subgroups for timely screening.
Publish Date	2025-08-07 06:39
Citation	<p>Li T, Feng Y, Wang M, Wang C, Gao F. Factors influencing diagnostic delays in celiac disease. <i>World J Gastroenterol</i> 2025; 31(30): 109585</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i30/109585.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i30.109585

Full Article (PDF)	WJG-31-109585-with-cover.pdf
STROBE Statement	109585-STROBE-statement.pdf
Manuscript File	109585_Auto_Edited_064736.docx
Answering Reviewers	109585-answering-reviewers.pdf
Audio Core Tip	109585-audio.mp3
Biostatistics Review Certificate	109585-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	109585-conflict-of-interest-statement.pdf
Copyright License Agreement	109585-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	109585-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	109585-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	109585-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	109585-non-native-speakers.pdf
Peer-review Report	109585-peer-reviews.pdf
Scientific Misconduct Check	109585-scientific-misconduct-check.png
Scientific Editor Work List	109585-scientific-editor-work-list.png
Scientific Editor Work List	109585-scientific-editor-work-list.pdf
CrossCheck Report	109585-crosscheck-report.pdf