| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Association of vascular invasion and tumor differentiation on post-liver transplant outcomes in patients with hepatocellular carcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Nazlı Begüm Öztürk, Merve M Gurakar, Ximena Parraga, Marwan Alsaqa, Leandro Sierra, Emily Currier, Butros Fakhoury, Alan Bonder, Ahmet Gurakar and Behnam Saberi |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Ahmet Gurakar, MD, Department of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Suite 918, Baltimore, MD 21205, United States. aguraka1@jhmi.edu |
| Key Words |
Hepatocellular carcinoma; Recurrence; Transplant; Vascular invasion; Cirrhosis |
| Core Tip |
Liver transplant (LT) is one of the treatment options for hepatocellular carcinoma (HCC). Macrovascular invasion and tumor differentiation have been shown to be associated with post-LT HCC recurrence. We investigated a large national transplant database in the United States to identify post-LT survival in HCC patients between 2012 and 2022. A total of 13638 patients with HCC and available liver explant data were included. Of the cohort, 254 (1.8%) demonstrated macrovascular invasion and 1712 (12.6%) had microvascular invasion (MVI). Poor tumor differentiation was most frequent in the macrovascular invasion cohort compared to the microvascular and absent invasion cohorts. Post-transplant survival at 1 year, 3 years, and 5 years was lowest among patients with macrovascular invasion, lower than in those with MVI and lower still than in those without vascular invasion. Likewise, on explant pathology, poor differentiation was linked to worse 1-year, 3-year, and 5-year survival than either well-differentiated tumors or complete necrosis. Macrovascular invasion and poor tumor differentiation on liver explants in patients with HCC were associated with significantly higher post-LT mortality, meaning that the extent of tumor involvement and tumor biology are important predictors of post-LT survival in HCC. |
| Publish Date |
2025-11-19 05:58 |
| Citation |
<p>Öztürk NB, Gurakar MM, Parraga X, Alsaqa M, Sierra L, Currier E, Fakhoury B, Bonder A, Gurakar A, Saberi B. Association of vascular invasion and tumor differentiation on post-liver transplant outcomes in patients with hepatocellular carcinoma. <i>World J Transplant</i> 2025; 15(4): 109609</p> |
| URL |
https://www.wjgnet.com/2220-3230/full/v15/i4/109609.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v15.i4.109609 |
