| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Comparative evaluation of three traditional herbal formulas on gastrointestinal motility in a mouse model of cold stress-induced dyspepsia
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Hua Wang, Song-Yi Han, Liangliang Wu, Uijeong Han, Si-Kyung Cho, Chan-Woong Park, Young-Won Chin, Mi Young Lim and Hojun Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea |
No. 2022M3A9E4017033 |
|
| Corresponding Author |
Hojun Kim, Division of Rehabilitation Medicine of Korean Medicine, Department of Oriental Rehabilitation Medicine, Dongguk University, Ilsan Hospital, 27 Dongguk-ro, Goyang 10326, South Korea. kimklar@dongguk.ac.kr |
| Key Words |
Non-alcoholic fatty liver disease; Alcoholic liver disease; Non-alcoholic steatohepatitis; Insulin resistance; Oxidative stress |
| Core Tip |
This study systematically compared the therapeutic effects of three classical herbal formulas (Pyeongwi-san, Shihosogan-tang, and Yijung-tang) in a mouse model of cold stress-induced dyspepsia. Among them, Pyeongwi-san was the most effective in restoring gastrointestinal motility, enhancing gastric acid secretion and upregulating digestive enzymes gene expression, and modulating serotonin, short-chain fatty acids, bile acid receptors, and glucagon-like peptide-1 signaling. These findings elucidate the mechanisms of Pyeongwi-san’s superior efficacy and strongly support its clinical application in treating cold-induced gastrointestinal dysfunction. |
| Publish Date |
2025-09-18 09:55 |
| Citation |
<p>Wang JH, Han SY, Wu L, Han U, Cho SK, Park CW, Chin YW, Lim MY, Kim H. Comparative evaluation of three traditional herbal formulas on gastrointestinal motility in a mouse model of cold stress-induced dyspepsia. <i>World J Gastroenterol</i> 2025; 31(35): 109808</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i35/109808.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i35.109808 |
