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10/15/2025 9:40:35 AM | Browse: 281 | Download: 580
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Received |
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2025-05-29 06:08 |
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Peer-Review Started |
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2025-06-06 09:03 |
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First Decision by Editorial Office Director |
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2025-06-22 10:36 |
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Return for Revision |
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2025-06-22 10:36 |
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Revised |
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2025-07-18 11:33 |
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Publication Fee Transferred |
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2025-07-19 02:09 |
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Second Decision by Editor |
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2025-08-26 00:10 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-05 07:15 |
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Articles in Press |
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2025-09-05 07:15 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-09 01:11 |
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Publish the Manuscript Online |
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2025-10-15 09:03 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Exosomal transfer of miR-375-3p from pancreatic β cells to hepatocytes impairs hepatic glycogenesis via Rbpj repression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fang-Zhi Xu, Lin Dou, Xi Wu, Chen-Xi Xia, Dong-Ni Yu, Yong Man, Tao Shen and Xiu-Qing Huang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National High Level Hospital Clinical Research Funding |
BJ-2024-219, BJ-2025-125 and BJ-2023-236 |
| Beijing Natural Science Foundation |
7252124 |
| National Key R&D Program of China |
2021YFE0114200 |
| National Natural Science Foundation of China |
82370584, 82470395 and 81600618 |
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| Corresponding Author |
Xiu-Qing Huang, PhD, The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, No. 1 Dahua Road, Dongdan, Dongcheng District, Beijing 100730, China. huang_xq118@126.com |
| Key Words |
Exosomes; Glycogenesis; Pancreatic β cell; MiR-375-3p; Hepatocytes |
| Core Tip |
Glucotoxic pancreatic β cells impair glycogenesis of hepatocytes, with exosomes serving as novel mediators. Glucotoxicity increased the expression of miR-375-3p in pancreatic cells but had no effect on hepatocytes. Exosomal transfer of miR-375-3p from pancreatic β cells to hepatocytes enables it to directly target and inhibit the recombination signal binding protein for the immunoglobulin kappa J region (Rbpj). This suppression of Rbpj subsequently impairs the AKT/GSK-3 signaling pathway, thereby reducing hepatic glycogen content. |
| Publish Date |
2025-10-15 09:03 |
| Citation |
Xu FZ, Dou L, Wu X, Xia CX, Yu DN, Man Y, Shen T, Huang XQ. Exosomal transfer of miR-375-3p from pancreatic β cells to hepatocytes impairs hepatic glycogenesis via Rbpj repression. World J Diabetes 2025; 16(10): 109815 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i10/109815.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i10.109815 |
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