Publication Name	World Journal of Hepatology
Manuscript ID	109898
Country	China

Received	2025-05-26 02:53
Peer-Review Started	2025-05-26 02:53
To Make the First Decision
Return for Revision	2025-05-31 09:50
Revised	2025-06-25 06:50
Second Decision	2025-09-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-11 07:16
Articles in Press	2025-09-11 07:16
Publication Fee Transferred	2025-06-30 15:18
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-10-15 09:06
Publish the Manuscript Online	2025-10-27 10:57

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatocyte nuclear factors dynamically regulate triglyceride metabolic reprogramming in metabolic dysfunction-associated steatotic liver disease: Mechanisms and implications
Manuscript Source	Unsolicited Manuscript
All Author List	Su-Qun Li, Jin-Hua Wu, Ying Zhou, Chen-Xi Wang, Li Xie, Si-Ying Liu, Yu-Zhi Su, Wei He, Huan Chen, Wei-Wei Zhong and Yi-Huai He
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Planning Projects of Guizhou Province QKHJC-MS[2025]384 Science and Technology Planning Projects of Zunyi City ZSKHHZ(2023)470 WBE Liver Fibrosis Foundation CFHPC2025028 Chinese Foundation for Hepatitis Prevention and Control Muxin Research Fund of Chronic Hepatitis B MX202404 Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund iGandanF-1082024-RGG018 Student Innovation and Entrepreneurship Training Program of Zunyi Medical University 2024106610923
Corresponding Author	Yi-Huai He, MD, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi 563000, Guizhou Province, China. 993565989@qq.com
Key Words	Hepatocyte nuclear factors; Metabolic dysfunction-associated steatotic liver disease; Triglyceride metabolic imbalance; Dynamic dysregulation of transcriptional networks; Clinical translation
Core Tip	Abnormal hepatic triglyceride deposition is the hallmark of metabolic dysfunction-associated steatotic liver disease. While this process may originate either as a hepatic manifestation of systemic metabolic dysfunction or direct local hepatic lipid metabolic imbalance, the two pathways dynamically interact to drive disease progression. Hepatocyte nuclear factors (HNFs) regulate hepatic triglyceride metabolism via transcriptional networks, and their dysfunction constitutes a key driver of metabolic dysfunction-associated steatotic liver disease pathogenesis. Targeting critical nodes in HNF regulatory networks presents new opportunities for precision therapy. This review systematically analyzes the clinical challenges involved in HNF-targeted therapies and explores potential solutions.
Publish Date	2025-10-27 10:57
Citation	<p>Li SQ, Wu JH, Zhou Y, Wang CX, Xie L, Liu SY, Su YZ, He W, Chen H, Zhong WW, He YH. Hepatocyte nuclear factors dynamically regulate triglyceride metabolic reprogramming in metabolic dysfunction-associated steatotic liver disease: Mechanisms and implications. <i>World J Hepatol</i> 2025; 17(10): 109898</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i10/109898.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i10.109898

Full Article (PDF)	WJH-17-109898-with-cover.pdf
Manuscript File	109898_Auto_Edited_083615.docx
Answering Reviewers	109898-answering-reviewers.pdf
Audio Core Tip	109898-audio.m4a
Conflict-of-Interest Disclosure Form	109898-conflict-of-interest-statement.pdf
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Non-Native Speakers of English Editing Certificate	109898-non-native-speakers.pdf
Peer-review Report	109898-peer-reviews.pdf
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Scientific Editor Work List	109898-scientific-editor-work-list.pdf
CrossCheck Report	109898-crosscheck-report.pdf