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8/11/2025 8:40:29 AM | Browse: 18 | Download: 59
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Received |
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2025-05-26 01:06 |
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Peer-Review Started |
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2025-05-26 01:06 |
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To Make the First Decision |
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Return for Revision |
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2025-06-10 07:12 |
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Revised |
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2025-06-21 11:33 |
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Second Decision |
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2025-07-29 02:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-29 08:03 |
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Articles in Press |
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2025-07-29 08:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-07 02:29 |
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Publish the Manuscript Online |
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2025-08-11 03:06 |
| ISSN |
2219-2816 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Basic Study |
| Article Title |
β-elemene inhibits bladder cancer cell through the expression of cell membrane protein GM3
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fang-Yin Li, Ying Wang and Yong-Jun Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Zhejiang Provincial Traditional Chinese Medicine Foundation |
No. 2021ZA021; and No. 2022ZZ005 |
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| Corresponding Author |
Yong-Jun Zhang, Associate Chief Physician, Department of Integration of Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital, No. 1 Banshan Eastern Road, Hangzhou 310022, Zhejiang Province, China. zhangyongjun770323@163.com |
| Key Words |
Beta-elemene; Bladder cancer; EGFR; GM3; Malignancy |
| Core Tip |
We believe that our study makes a significant contribution to the literature because GEPIA2 database deep mining revealed that GM3 was poorly expressed in bladder cancer (BLCA), and this study showed that beta-elemene inhibited BLCA cells by increasing GM3 expression. Moreover, cluster analysis showed that GM3 increased cell adhesion and inhibited the invasion and migration of BLCA cells by expressing membrane-related signaling proteins. Further, we believe that this paper will be of interest to the readership of your journal because the use of beta-elemene in anti-cancer medication is advantageous owing to its significant anti-tumor activity against various types of cancer and its reduced toxicity, which ensures that its impact on the quality of life of patients with cancer is minimal and the drug is well tolerated. Thus, this study provides a preliminary basis and strong evidence for further research on the underlying molecular mechanisms of beta-elemene in the treatment of BLCA. |
| Publish Date |
2025-08-11 03:06 |
| Citation |
<p>Li FY, Wang Y, Zhang YJ. β-elemene inhibits bladder cancer cell through the expression of cell membrane protein GM3. <i>World J Clin Urol</i> 2025; 14(2): 109933</p> |
| URL |
https://www.wjgnet.com/2219-2816/full/v14/i2/109933.htm |
| DOI |
https://dx.doi.org/10.5410/wjcu.v14.i2.109933 |
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