| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Clinicopathological insights and management of liver metastases: Current advances and future perspectives
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Noura A A Ebrahim, Thoraya A Farghaly, Ahmed Abdo El-Sherif, Ahmed M Fahmy, Moamen O Othman, Neveen S Tahoun, Omnia Mohamed Korany, Aya Arafat, Reham Oreaba and Soliman M A Soliman |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| UMM Al-Qura University, Saudi Arabia |
No. 25UQU4350477GSSR05 |
|
| Corresponding Author |
Soliman M A Soliman, MD, PhD, Department of Chemistry, Faculty of Science, Cairo University, 1 Gamaa Street, Cairo 12613, Al Qahirah, Egypt. sabdellatif@sci.cu.edu.eg |
| Key Words |
Liver metastases; Histopathological growth patterns; Liquid biopsy; Molecular profiling; Systemic therapy; Locoregional treatment; Artificial intelligence; Radiomics; Organoids; Precision oncology |
| Core Tip |
Liver metastases remain one of the most significant contributors to cancer-related deaths, occurring far more frequently than primary hepatic tumors. This review delivers a thorough overview of current clinicopathological understanding, diagnostic imaging innovations, and evolving treatment approaches for managing liver metastases. It underscores the prognostic relevance of distinct histological growth patterns and the expanding clinical value of liquid biopsy techniques, molecular characterization, and multidisciplinary management strategies. Additionally, the review discusses emerging precision oncology tools-including artificial intelligence, radiomics, and patient-derived organoid models-that are shaping the future of personalized care for patients with metastatic liver disease. |
| Publish Date |
2025-10-27 10:57 |
| Citation |
<p>Ebrahim NAA, Farghaly TA, El-Sherif AA, Fahmy AM, Othman MO, Tahoun NS, Korany OM, Arafat A, Oreaba R, Soliman SMA. Clinicopathological insights and management of liver metastases: Current advances and future perspectives. <i>World J Hepatol</i> 2025; 17(10): 110026</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i10/110026.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i10.110026 |
