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10/24/2025 6:21:31 AM | Browse: 24 | Download: 69
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Received |
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2025-06-07 04:12 |
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Peer-Review Started |
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2025-06-07 04:12 |
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To Make the First Decision |
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Return for Revision |
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2025-07-03 09:18 |
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Revised |
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2025-07-15 17:06 |
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Second Decision |
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2025-09-25 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-25 23:09 |
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Articles in Press |
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2025-09-25 23:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-17 08:28 |
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Publish the Manuscript Online |
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2025-10-24 06:10 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lin Huang and Juan He |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Project of Health Commission of Guangxi Zhuang Autonomous Region |
Z-A20240546 |
| Undergraduate Education and Teaching Reform Project of Guangxi Medical University |
2025XJGYC38 |
| Key Textbook Construction Project of Guangxi Medical University |
Gxmuzdjc2417 |
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| Corresponding Author |
Juan He, Professor, Researcher, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. hejuan@stu.gxmu.edu.cn |
| Key Words |
Upper tract urothelial carcinoma; Human epidermal growth factor receptor 2; Clinicopathological features; Tumor grade; Relationship |
| Core Tip |
This is a retrospective single-center observational study to evaluate human epidermal growth factor receptor 2 (HER2) expression patterns by immunohistochemistry in 145 upper tract urothelial carcinoma (UTUC) specimens and assessed its correlation with tumor grade, stage, molecular subtype, and other clinicopathological parameters. HER2 overexpression in UTUC is strongly linked to tumor dedifferentiation (high grade), while other variables including sex, anatomical tumor location, pathological T stage, Ki-67 proliferation index, nodal metastasis status, lymphovascular invasion, and tumor laterality all failed to demonstrate statistically meaningful correlations. This distinct pattern suggests HER2 may play a unique biological role in UTUC compared to other epithelial malignancies. |
| Publish Date |
2025-10-24 06:10 |
| Citation |
<p>Huang L, He J. Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma. <i>World J Clin Oncol</i> 2025; 16(10): 110047</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i10/110047.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i10.110047 |
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