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9/11/2025 9:45:46 AM | Browse: 205 | Download: 69
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Received |
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2025-05-28 13:10 |
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Peer-Review Started |
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2025-05-30 00:09 |
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To Make the First Decision |
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Return for Revision |
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2025-06-12 02:07 |
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Revised |
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2025-06-25 12:59 |
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Second Decision |
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2025-08-14 03:08 |
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Accepted by Journal Editor-in-Chief |
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2025-08-17 10:43 |
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Accepted by Executive Editor-in-Chief |
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2025-08-19 08:21 |
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Articles in Press |
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2025-08-19 08:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-08-24 21:52 |
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Typeset the Manuscript |
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2025-09-03 08:20 |
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Publish the Manuscript Online |
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2025-09-11 09:42 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Diabetic gastrointestinal autonomic neuropathy: Integrating neuronal degeneration and gut microbial dysbiosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mei-Xia Zhou, Yu Zhao, Chen-Ling Chu, Tapas Ranjan Behera, Quan-Quan Shen and Yu-Bo Xing |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Zhejiang Province |
LY23H050005 |
| Zhejiang Medical Technology Project |
2022RC009 |
| Zhejiang Medical Technology Project |
2023XY238 |
| Zhejiang Medical Technology Project |
2024KY645 |
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| Corresponding Author |
Quan-Quan Shen, Department of Nephrology, Zhejiang Provincial People’s Hospital, No. 112 Guanghui Road, Hangzhou, Zhejiang 310014, Zhejiang, China. spring198457@sina.com |
| Key Words |
Diabetic neuropathy; Gastrointestinal; Enteric neuropathy; Diabetes; Neuropathy; Gut microbiota |
| Core Tip |
Diabetic gastrointestinal autonomic neuropathy (DGAN) represents a complex pathophysiological cascade driven by bidirectional interactions between hyperglycemia-induced neuronal injury and gut microbiota dysbiosis. Chronic hyperglycemia triggers oxidative stress, inflammatory pathways, and neurotrophic factor deficits, leading to damage of enteric neurons and glia. Concurrently, diabetes-associated dysbiosis reduces microbial diversity and beneficial metabolite production, which further exacerbates neuroinflammation and autonomic dysfunction. Advanced multi-omics approaches reveal these mechanisms, aiding early diagnosis through microbiome profiling and functional synaptic imaging. Therapeutic strategies targeting microbiota restoration, oxidative stress reduction, and neuroprotection show promise. Future research should prioritize large-scale clinical trials and metabolite-targeted interventions to advance personalized management of DGAN. |
| Publish Date |
2025-09-11 09:42 |
| Citation |
<p>Zhou MX, Zhao Y, Chu CL, Behera TR, Shen QQ, Xing YB. Diabetic gastrointestinal autonomic neuropathy: Integrating neuronal degeneration and gut microbial dysbiosis. <i>World J Diabetes</i> 2025; 16(9): 110053</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i9/110053.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i9.110053 |
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