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10/21/2025 9:33:25 AM | Browse: 435 | Download: 628
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Received |
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2025-05-30 07:14 |
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Peer-Review Started |
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2025-05-30 07:14 |
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First Decision by Editorial Office Director |
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2025-06-27 08:26 |
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Return for Revision |
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2025-06-27 08:26 |
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Revised |
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2025-07-11 09:13 |
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Publication Fee Transferred |
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2025-07-24 01:05 |
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Second Decision by Editor |
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2025-09-15 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-15 06:11 |
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Articles in Press |
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2025-09-15 06:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-15 09:10 |
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Publish the Manuscript Online |
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2025-10-21 09:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Xing Wang, Ming-Ze Ma, Li-Chao Zhu, Long-Fei Dai, Chuan Qin, Shuai Shao, Xian-Wen Xu, Ru-Xin Gao and Zhen-Hai Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82000579 and 81870205 |
| Natural Science Foundation of Shandong Province |
ZR2021QH061 and ZR2021QH186 |
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| Corresponding Author |
Zhen-Hai Zhang, Department of Hepatobiliary Surgery, Shandong Provincial Hospital, Shandong University, No. 324 Jingwu Road, Huaiyin District, Jinan 250021, Shandong Province, China. drzhangzhenhai@163.com |
| Key Words |
Basic Study |
| Core Tip |
Cholelithiasis is a common biliary disorder with complex mechanisms. Lysine succinylation, a protein post-translational modification, remains unstudied in this condition. This study reveals that lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase (AMPK) inhibits cholelithiasis by regulating inflammation via the AMPK/sirtuin 1 pathway. This study provides a groundbreaking perspective on cholelithiasis mechanisms and position succinylation as a potential therapeutic target, addressing a significant gap in the field. |
| Publish Date |
2025-10-21 09:08 |
| Citation |
Wang XX, Ma MZ, Zhu LC, Dai LF, Qin C, Shao S, Xu XW, Gao RX, Zhang ZH. Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosis. World J Gastroenterol 2025; 31(39): 110115
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| URL |
https://www.wjgnet.com/1007-9327/full/v31/i39/110115.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i39.110115 |
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