| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Minireviews |
| Article Title |
Extracellular vesicles from adipose-derived stem cells in bone regeneration: Mechanisms and therapeutic advances
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
An Lin, Jia-Lu Yu, Sheng-Meng Yuan, Ying-Feng Tang, Ke-Xin Yang, Yu-Hao Wang, Fang-Jun Huo, Zhao-Rui Jin, Qi Xiao, Chao Yang and Wei-Dong Tian |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program of China |
2022YFA1104400 |
| National Natural Science Foundation of China |
U21A20369 |
|
| Corresponding Author |
Chao Yang, Department of Research and Development, Chengdu Shiliankangjian Biotechnology Co., Ltd, No. 366 Hemin Street, Chengdu High-Tech Zone, Chengdu 610213, Sichuan Province, China. yangchao1207@qq.com |
| Key Words |
Adipose-derived stem cell; Extracellular vesicle; Bone regeneration; Fracture healing; Osteoarthritis; Osteoporosis; Therapeutic mechanism |
| Core Tip |
Extracellular vesicles derived from adipose-derived stem cells exhibit significant potential in bone regeneration. They mediate osteogenesis, angiogenesis, and immunomodulation via bioactive molecules, with translational strategies including preconditioning, cargo engineering, and biomaterial integration. This review summarizes their efficacy in fractures, osteoarthritis, and osteoporosis, and discusses clinical translation challenges. |
| Publish Date |
2025-10-25 01:11 |
| Citation |
<p>Lin A, Yu JL, Yuan SM, Tang YF, Yang KX, Wang YH, Huo FJ, Jin ZR, Xiao Q, Yang C, Tian WD. Extracellular vesicles from adipose-derived stem cells in bone regeneration: Mechanisms and therapeutic advances. <i>World J Stem Cells</i> 2025; 17(10): 110248</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i10/110248.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i10.110248 |
