| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Case Control Study |
| Article Title |
MicroRNAs in colorectal cancer: A comparative analysis of circulating and tissue microRNA levels
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Iulia Andreea Pelisenco, Bogdan Trandafir, Anastasia-Maria Dobre, Andrei-Daniel Dragne, Vlad Herlea, Andrei Marian Niculae, Catalin Vasilescu, Mihail Eugen Hinescu, Elena Milanesi and Maria Dobre |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| European Union’s NextGeneration PNRR-III-C9-2022-I5, managed by the Ministry of Research, Innovation and Digitization |
760009/30.12.2022, code CF 14/16.11.2022 |
| Ministry of Research, Innovation and Digitization of Romania |
PN 23.16.02.04 |
|
| Corresponding Author |
Elena Milanesi, Assistant Professor, Senior Researcher, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, No. 8, Sector 5, Eroii Sanitari Boulevard, Bucharest 050474, Romania. elena.k.milanesi@gmail.com |
| Key Words |
Colorectal cancer; MicroRNAs; Biomarker; Plasma; Colonic mucosa; Lymphovascular invasion |
| Core Tip |
In this case-control study, we analyzed the levels of 84 microRNAs in tumoral and peritumoral colonic mucosa of 19 patients with colorectal cancer compared to those expressed in the normal mucosa from 18 controls. For each patient, we also investigated the levels of 179 circulating microRNAs in comparison with a cohort of 16 controls. A relationship between tissue and plasma levels has been established along with correlations with tumoral features. Five microRNAs (miR-26b-5p, miR-101-3p, miR-30d-5p, miR-107, and miR-21-5p) presented the same trend in terms of fold change in both biological samples, suggesting them as putative non-invasive biomarkers for monitoring colorectal cancer progression. |
| Publish Date |
2025-11-14 00:56 |
| Citation |
<p>Pelisenco IA, Trandafir B, Dobre AM, Dragne AD, Herlea V, Niculae AM, Vasilescu C, Hinescu ME, Milanesi E, Dobre M. MicroRNAs in colorectal cancer: A comparative analysis of circulating and tissue microRNA levels. <i>World J Gastrointest Oncol</i> 2025; 17(11): 110266</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i11/110266.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i11.110266 |
