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11/26/2025 4:02:02 AM | Browse: 9 | Download: 45
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Received |
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2025-06-07 01:45 |
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Peer-Review Started |
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2025-06-07 01:45 |
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To Make the First Decision |
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Return for Revision |
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2025-06-26 03:03 |
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Revised |
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2025-07-29 15:09 |
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Second Decision |
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2025-09-29 00:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-10-09 08:28 |
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Articles in Press |
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2025-10-09 08:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-10-12 20:45 |
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Typeset the Manuscript |
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2025-11-20 02:14 |
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Publish the Manuscript Online |
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2025-11-26 03:57 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Cancer cell-dependent increase in senescence-like populations following exosome treatment from bone marrow and induced pluripotent stem cells-derived mesenchymal stem cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nidaa A Ababneh, Sura Nashwan, Razan AlDiqs, Mohammad A Ismail, Ahmed A Abdulelah, Anas H A Abu-Humaidan, Lina AlQirem, Khairallah Al-Abdallat, Talal Al-Qaisi, Tareq Saleh and Abdalla Awidi |
| Funding Agency and Grant Number |
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| Corresponding Author |
Nidaa A Ababneh, Associate Professor, Cell Therapy Center, University of Jordan, Amman 11942, Jordan. n.ababneh@ju.edu.jo |
| Key Words |
Bone marrow-derived stromal cells; Induced pluripotent stem cells-derived mesenchymal stem cells; Cell-free cancer therapy; Exosomes; Breast cancer; Pancreatic cancer; Senescence-associated secretory phenotype |
| Core Tip |
This study explores the effects of exosomes (Exos) obtained from bone marrow mesenchymal stem cells (MSCs) and MSCs derived from induced pluripotent stem cells (iMSCs) on pancreatic and triple-negative breast cancer cells. iMSC-derived Exos exhibited a stronger and sustained anti-proliferative effect by inducing a senescence-like state without apoptosis. In contrast, bone marrow MSC-derived Exos showed variable effects depending on cancer type. These findings highlight the importance of Exos source in determining therapeutic outcomes and suggest senescence induction as a key response to Exos exposure. |
| Publish Date |
2025-11-26 03:57 |
| Citation |
<p>Ababneh NA, Nashwan S, AlDiqs R, Ismail MA, Abdulelah AA, Abu-Humaidan AHA, AlQirem L, Al-Abdallat K, Al-Qaisi T, Saleh T, Awidi A. Cancer cell-dependent increase in senescence-like populations following exosome treatment from bone marrow and induced pluripotent stem cells-derived mesenchymal stem cells. <i>World J Stem Cells</i> 2025; 17(11): 110381</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i11/110381.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i11.110381 |
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