Publication Name	World Journal of Diabetes
Manuscript ID	110428
Country	Nigeria

Received	2025-06-06 16:49
Peer-Review Started	2025-06-11 00:04
To Make the First Decision
Return for Revision	2025-06-24 09:40
Revised	2025-08-02 10:31
Second Decision	2025-09-16 00:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-26 08:18
Articles in Press	2025-09-26 08:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-10-01 18:38
Typeset the Manuscript	2025-11-03 07:59
Publish the Manuscript Online	2025-11-14 08:23

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Physiology
Manuscript Type	Minireviews
Article Title	Diabetic neuropathy and wound healing: An update on the epigenetic crosstalk
Manuscript Source	Invited Manuscript
All Author List	Kamaldeen Olalekan Sanusi, Jerome Ndudi Asiwe, Fatimo Ajoke Sulaimon, Farida Bashar, Suleiman Kolawole Yusuf and Hawau Olaide Abdulkadir
Funding Agency and Grant Number
Corresponding Author	Kamaldeen Olalekan Sanusi, Head, Lecturer, PhD, Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Al-Hikmah University, Adewole Estate, Adeta Road, Kwara State, P.M.B. 1601, Ilorin 240244, Nigeria. sanusikamaldeen@yahoo.com
Key Words	Diabetic neuropathy; Wound healing; Diabetic foot ulcers; Epigenetics; Inflammation; Metabolic memory; Precision medicine
Core Tip	Diabetic neuropathy and impaired wound healing in diabetic foot ulcers are significant complications of diabetes. They are driven by complex molecular mechanisms involving epigenetic modifications such as DNA methylation, histone modifications, and non-coding RNAs. These epigenetic alterations contribute to inflammatory responses, neuronal degeneration, and disrupted tissue repair, with "metabolic memory" causing long-lasting molecular imprints even after blood glucose normalization. This emerging understanding of the epigenetic interplay provides a comprehensive framework for disease development and opens new avenues for targeted therapies and biomarkers to improve clinical outcomes beyond traditional glucose-centric views.
Publish Date	2025-11-14 08:23
Citation	<p>Sanusi KO, Asiwe JN, Sulaimon FA, Bashar F, Yusuf SK, Abdulkadir HO. Diabetic neuropathy and wound healing: An update on the epigenetic crosstalk. <i>World J Diabetes</i> 2025; 16(11): 110428</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i11/110428.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i11.110428

Full Article (PDF)	WJD-16-110428-with-cover.pdf
Manuscript File	110428_Auto_Edited_022904.docx
Answering Reviewers	110428-answering-reviewers.pdf
Audio Core Tip	110428-audio.mp3
Conflict-of-Interest Disclosure Form	110428-conflict-of-interest-statement.pdf
Copyright License Agreement	110428-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	110428-non-native-speakers.pdf
Peer-review Report	110428-peer-reviews.pdf
Journal Editor-in-Chief Review Report	110428-journal-editor-in-chief.pdf
Scientific Misconduct Check	110428-scientific-misconduct-check.png
Scientific Editor Work List	110428-scientific-editor-work-list.pdf
CrossCheck Report	110428-crosscheck-report.pdf