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10/25/2025 1:09:40 PM | Browse: 111 | Download: 174
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Received |
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2025-06-10 04:48 |
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Peer-Review Started |
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2025-06-10 04:48 |
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To Make the First Decision |
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Return for Revision |
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2025-06-18 02:27 |
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Revised |
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2025-07-01 10:07 |
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Second Decision |
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2025-09-01 00:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-08 11:06 |
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Articles in Press |
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2025-09-08 11:06 |
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Publication Fee Transferred |
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2025-07-03 01:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-20 00:21 |
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Publish the Manuscript Online |
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2025-10-25 01:11 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Basic Study |
| Article Title |
Efficacy of extracellular vesicles derived from mesenchymal stromal cells in regulating senescence: In vitro and in vivo insights
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shuang-Shuang Yang, Si-Yu Chen, Wen-Ya Zhuang, Jing Han, Ya Liu, Li Deng, Hui-Zhen Guo, He-Ran Ma and Yi Tan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Science and Technology of China |
2021YFA1101502 |
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| Corresponding Author |
Yi Tan, Department of Research and Development, Qilu Cell Therapy Technology Co. Ltd., No. 6 Gangyuan Road, Jinan 250100, Shandong Province, China. pkuty@126.com |
| Key Words |
Senescence; Anti-aging; Mesenchymal stromal cells; Extracellular vesicles; Transcriptomics; Metabolomics |
| Core Tip |
This study addresses the practical challenges of using mesenchymal stromal cell-derived extracellular vesicles (EVs) for anti-aging therapy. We developed a scalable production method and quality control standards for clinical use. Tests in cells and animals have shown that these EVs effectively decrease the expression of aging markers, repair age-related damage, reduce oxidative stress, and normalize gene activity. The key mechanisms involved in fighting oxidative stress and fine-tuning metabolism. These findings position EVs as promising, ready-to-use anti-aging treatments. |
| Publish Date |
2025-10-25 01:11 |
| Citation |
<p>Yang SS, Chen SY, Zhuang WY, Han J, Liu Y, Deng L, Guo HZ, Ma HR, Tan Y. Efficacy of extracellular vesicles derived from mesenchymal stromal cells in regulating senescence: In vitro and in vivo insights. <i>World J Stem Cells</i> 2025; 17(10): 110445</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i10/110445.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i10.110445 |
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