| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Review |
| Article Title |
Pinocembrin as a novel anti-cancer agent: Exploring preclinical evidence along with therapeutic potential
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Neelam Singla, Piyush Mittal, M Arockia Babu, Soumya V Menon, Subhashree Ray, Haider Ali, Manish Purohit, Kavita Goyal, Rakhi Mishra, Md Sadique Hussain, Arcot Rekha and Gaurav Gupta |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Gaurav Gupta, Additional Professor, Adjunct Professor, Chairman, Consultant, Full Professor, PhD, Post Doctoral Researcher, Postdoc, Professor, Research Dean, Researcher, Senior Scientist, Visiting Professor, Centre for Research Impact and Outcome-Chitkara College of Pharmacy, Chitkara University, Chitkara, Rajpura 433221, Punjab, India. gauravpharma25@gmail.com |
| Key Words |
Pinocembrin; Flavonoid; Anticancer activity; Pharmacokinetics; Nanoparticle delivery; Apoptosis |
| Core Tip |
Pinocembrin (PB) (5,7-dihydroxy flavanone), a natural flavonoid sourced from propolis and Pinus species, shows promising anticancer potential through multiple mechanisms including mitochondrial apoptosis induction, phosphoinositol-3 kinase/protein kinase B and STAT3 pathway inhibition, and suppression of metastatic markers such as matrix metalloproteinase-9 and vascular endothelial growth factor. Preclinical studies have demonstrated significant tumor growth inhibition and enhanced pharmacokinetics when PB is formulated into advanced nanocarrier systems, like MPEG-PDLLA micelles and D-α-tocopheryl polyethylene glycol 1000 succinate liposomes. These formulations notably improve its otherwise limited oral bioavailability and systemic retention. With a favorable toxicity profile, PB emerges as a compelling candidate for further clinical translation in oncology. |
| Publish Date |
2025-12-19 08:32 |
| Citation |
Singla N, Mittal P, Babu MA, V Menon S, Ray S, Ali H, Purohit M, Goyal K, Mishra R, Hussain MS, Rekha A, Gupta G. Pinocembrin as a novel anti-cancer agent: Exploring preclinical evidence along with therapeutic potential. World J Exp Med 2025; 15(4): 110482 |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i4/110482.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i4.110482 |
