Publication Name	World Journal of Hepatology
Manuscript ID	110614
Country	China

Received	2025-06-12 04:02
Peer-Review Started	2025-06-12 04:03
To Make the First Decision
Return for Revision	2025-07-13 03:11
Revised	2025-07-14 12:07
Second Decision	2025-09-28 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-28 08:18
Articles in Press	2025-09-28 08:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-10-31 13:04
Publish the Manuscript Online	2025-11-27 07:53

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Pre-transplant downstaging strategies for hepatocellular carcinoma with portal vein tumor thrombus: Current therapies and future challenges
Manuscript Source	Invited Manuscript
All Author List	Zong-Yang Li, Cheng Xie and Hong-Qiao Cai
Funding Agency and Grant Number
Corresponding Author	Hong-Qiao Cai, MD, PhD, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. hongqiaocai@jlu.edu.cn
Key Words	Hepatocellular carcinoma; Portal vein tumor thrombus; Liver transplantation; Downstaging therapy; Transarterial chemoembolization
Core Tip	Hepatocellular carcinoma with portal vein tumor thrombus has long been considered a contraindication for liver transplantation due to poor prognosis. However, evolving downstaging strategies, including transarterial chemoembolization, transarterial radioembolization, proton beam therapy, and combination immunotherapies, have shown potential to convert select patients into transplant candidates. This review summarizes current clinical evidence and highlights future directions involving personalized medicine, novel biomaterials, and standardized criteria.
Publish Date	2025-11-27 07:53
Citation	<p>Li ZY, Xie C, Cai HQ. Pre-transplant downstaging strategies for hepatocellular carcinoma with portal vein tumor thrombus: Current therapies and future challenges. <i>World J Hepatol</i> 2025; 17(11): 110614</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i11/110614.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i11.110614

Full Article (PDF)	WJH-17-110614-with-cover.pdf
Manuscript File	110614_Auto_Edited_022042.docx
Answering Reviewers	110614-answering-reviewers.pdf
Audio Core Tip	110614-audio.mp3
Conflict-of-Interest Disclosure Form	110614-conflict-of-interest-statement.pdf
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Non-Native Speakers of English Editing Certificate	110614-non-native-speakers.pdf
Peer-review Report	110614-peer-reviews.pdf
Scientific Misconduct Check	110614-scientific-misconduct-check.png
Scientific Editor Work List	110614-scientific-editor-work-list.pdf
CrossCheck Report	110614-crosscheck-report.pdf