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12/23/2025 7:33:40 AM | Browse: 14 | Download: 38
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Received |
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2025-06-18 07:08 |
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Peer-Review Started |
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2025-06-18 07:08 |
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2025-07-19 02:02 |
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2025-07-19 02:02 |
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Revised |
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2025-08-01 16:29 |
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Second Decision by Editor |
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2025-11-12 02:44 |
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Final Decision by Editorial Office Director |
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2025-11-13 04:22 |
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Articles in Press |
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2025-11-13 04:22 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-10 01:27 |
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Publish the Manuscript Online |
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2025-12-23 06:25 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Pathogenicity of Helicobacter pylori-associated gastric cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shamshul Ansari and Nada Ahmed |
| Funding Agency and Grant Number |
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| Corresponding Author |
Shamshul Ansari, Assistant Professor, PhD, Division of Health Sciences, Higher Colleges of Technology, Baniyas, Abu Dhabi 25026, United Arab Emirates. shamshulansari483@yahoo.com |
| Key Words |
Gastric cancer; Helicobacter pylori; Virulence factors; GagA; cagPAI; Microbiome |
| Core Tip |
The factors beyond the well-known bacterial toxins, CagA and VacA, influence disease progression. Helicobacter pylori infection can cause DNA double-strand breaks and create a hypoxic environment in the stomach lining. This activates hypoxia-inducible factors, which promote processes like tissue remodeling, new blood vessel formation, and the appearance of cancer stem cell-like populations. At the same time, infection-driven changes in regulatory molecules such as microRNAs and long non-coding RNAs can silence tumor-suppressor genes and disrupt immune control. Together, these emerging factors amplify the damage initiated by bacterial virulence factors, accelerating the transformation of normal gastric cells into cancerous ones. |
| Publish Date |
2025-12-23 06:25 |
| Citation |
Ansari S, Ahmed N. Pathogenicity of Helicobacter pylori-associated gastric cancer. World J Clin Oncol 2025; 16(12): 110909 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i12/110909.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i12.110909 |
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