Publication Name	World Journal of Hepatology
Manuscript ID	110964
Country	Afghanistan

Received	2025-06-19 03:27
Peer-Review Started	2025-06-19 03:27
To Make the First Decision
Return for Revision	2025-07-11 10:25
Revised	2025-07-23 15:45
Second Decision	2025-08-25 03:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-25 09:18
Articles in Press	2025-08-25 09:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-17 03:19
Publish the Manuscript Online	2025-09-25 11:24

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Melatonin’s anti-inflammatory and antioxidant effects in gallstone disease: A narrative review
Manuscript Source	Unsolicited Manuscript
All Author List	Umaimah Batool Mirza, Imteshal Sarfaraz, Zunaira Kiran, Daniyal Sohail, Rahim Khan, Ahmed Asad Raza and Abedin Samadi
Funding Agency and Grant Number
Corresponding Author	Abedin Samadi, MD, Department of Internal Medicine, Kabul University of Medical Sciences Abu Ali Sina, Ataturk Avenue, Jamal Mena, 3rd District, Kabul 1006, Afghanistan. abedinsamadi4@gmail.com
Key Words	Gallstone disease; Cholelithiasis; Cholesterol stones; Biliary obstruction; Gallbladder motility dysfunction; Melatonin; Antioxidant; Anti-inflammatory
Core Tip	Emerging research highlights melatonin as a novel adjunct in gallstone disease management due to its antioxidant, anti-inflammatory, and lipid-regulating properties. Melatonin reduces biliary cholesterol saturation, enhances gallbladder motility, and protects epithelial cells from oxidative stress, addressing key mechanisms of gallstone formation. Its excellent safety profile and potential to prevent recurrence make it a promising non-invasive option, particularly for high-risk or surgery-resistant patients.
Publish Date	2025-09-25 11:24
Citation	<p>Batool Mirza U, Sarfaraz I, Kiran Z, Sohail D, Khan R, Raza AA, Samadi A. Melatonin’s anti-inflammatory and antioxidant effects in gallstone disease: A narrative review. <i>World J Hepatol</i> 2025; 17(9): 110964</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i9/110964.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i9.110964

Full Article (PDF)	WJH-17-110964-with-cover.pdf
Manuscript File	110964_Auto_Edited_033654.docx
Answering Reviewers	110964-answering-reviewers.pdf
Audio Core Tip	110964-audio.m4a
Conflict-of-Interest Disclosure Form	110964-conflict-of-interest-statement.pdf
Copyright License Agreement	110964-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	110964-non-native-speakers.pdf
Peer-review Report	110964-peer-reviews.pdf
Scientific Misconduct Check	110964-scientific-misconduct-check.png
Scientific Editor Work List	110964-scientific-editor-work-list.pdf
CrossCheck Report	110964-crosscheck-report.pdf