Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110981
Country	China

Received	2025-06-20 05:42
Peer-Review Started	2025-06-20 05:42
To Make the First Decision
Return for Revision	2025-06-30 06:32
Revised	2025-07-02 02:13
Second Decision	2025-07-31 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-31 07:18
Articles in Press	2025-07-31 07:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-08-04 22:47
Typeset the Manuscript	2025-09-02 02:29
Publish the Manuscript Online	2025-09-15 08:38

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Wen Huang, Chen Lin, Chen-Jia Lu, Hua-Shou Wang and Dan-Dan Zou
Funding Agency and Grant Number
Corresponding Author	Chen Lin, Department of Pathology, People’s Hospital of Longhua District, No. 38 Jinglong Jianshe Road, Longhua District, Shenzhen 518110, Guangdong Province, China. chenlincc2024@163.com
Key Words	Gastrin; Gastric cancer; Helicobacter pylori; Pathological characteristics; Survival curve
Core Tip	This study explores the clinical relevance of serum gastrin and Helicobacter pylori infection in gastric cancer. Among 226 patients, elevated serum gastrin, but not Helicobacter pylori status, was significantly associated with advanced tumor stage, lymphatic metastasis, and poor differentiation. Notably, gastrin-positive patients had worse overall survival. These findings suggest that hypergastrinemia may serve as a biomarker of tumor aggressiveness and prognosis in gastric cancer, offering potential targets for risk stratification and therapeutic intervention.
Publish Date	2025-09-15 08:38
Citation	<p>Huang JW, Lin C, Lu CJ, Wang HS, Zou DD. Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer. <i>World J Gastrointest Oncol</i> 2025; 17(9): 110981</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i9/110981.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i9.110981

Full Article (PDF)	WJGO-17-110981-with-cover.pdf
STROBE Statement	110981-STROBE-statement.pdf
Manuscript File	110981_Auto_Edited_013619.docx
Answering Reviewers	110981-answering-reviewers.pdf
Audio Core Tip	110981-audio.mp3
Biostatistics Review Certificate	110981-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	110981-conflict-of-interest-statement.pdf
Copyright License Agreement	110981-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	110981-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	110981-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	110981-non-native-speakers.pdf
Peer-review Report	110981-peer-reviews.pdf
Scientific Misconduct Check	110981-scientific-misconduct-check.png
Scientific Editor Work List	110981-scientific-editor-work-list.pdf
CrossCheck Report	110981-crosscheck-report.pdf