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12/23/2025 7:33:40 AM | Browse: 12 | Download: 26
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Received |
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2025-06-23 01:13 |
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Peer-Review Started |
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2025-06-23 01:14 |
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First Decision by Editorial Office Director |
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2025-07-15 09:55 |
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Return for Revision |
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2025-07-15 09:55 |
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Revised |
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2025-07-28 11:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-13 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-13 10:47 |
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Articles in Press |
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2025-11-13 10:47 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-10 01:28 |
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Publish the Manuscript Online |
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2025-12-23 06:25 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Provoking myofibroblast death: Strategies to resolve fibrosis and remodel tumor microenvironment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Thangavelu Shalini and Ganapasam Sudhandiran |
| Funding Agency and Grant Number |
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| Corresponding Author |
Ganapasam Sudhandiran, Associate Professor, PhD, Professor, Cell Biology Laboratory, Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamil Nādu, India. sudhandiran@yahoo.com |
| Key Words |
Myofibroblast apoptosis; Fibrosis resolution; Tumor microenvironment; Extracellular matrix remodeling; Fibroblast activation; Cancer-associated fibroblasts; Mechanotransduction in fibrosis |
| Core Tip |
Myofibroblasts are contractile cells that play a central role in both fibrosis and tumor progression due to their involvement in excessive extracellular matrix deposition and tissue stiffening. This article highlights emerging strategies to selectively inactivate or induce myofibroblast death, aiming to resolve fibrosis and remodel the tumor microenvironment. By exploring diverse disease models of fibrosis and cancer, this review underscores the therapeutic potential of targeting myofibroblasts to halt chronic tissue damage and improve cancer treatment outcomes. |
| Publish Date |
2025-12-23 06:25 |
| Citation |
Shalini T, Sudhandiran G. Provoking myofibroblast death: Strategies to resolve fibrosis and remodel tumor microenvironment. World J Clin Oncol 2025; 16(12): 111086 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i12/111086.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i12.111086 |
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