Publication Name	World Journal of Immunology
Manuscript ID	111119
Country	Indonesia

Received	2025-06-24 12:08
Peer-Review Started	2025-06-25 00:35
To Make the First Decision
Return for Revision	2025-07-02 02:56
Revised	2025-07-03 07:21
Second Decision	2025-10-28 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-29 02:41
Articles in Press	2025-10-29 02:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-11-06 00:23
Publish the Manuscript Online	2025-11-17 03:52

ISSN	2219-2824 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Allergy
Manuscript Type	Prospective Study
Article Title	Role of IgE cells in the exacerbation and management of asthma: An experimental study
Manuscript Source	Invited Manuscript
All Author List	Agussalim Agussalim, Citrawati Citrawati and Adriyani Adam
Funding Agency and Grant Number
Corresponding Author	Agussalim Agussalim, Associate Professor, PhD, Department of Nursing, Makassar Health Polytechnic, Jalan Banta Bantaeng, Makassar city, Makassar 92152, Sulawesi Selatan, Indonesia. salim170878@gmail.com
Key Words	Experimental study; Anti-IgE therapy; Allergic inflammation; IgE; Asthma
Core Tip	Asthma is a chronic respiratory disease driven in part by immune mechanisms involving IgE. This experimental study highlights the significant role of IgE in asthma exacerbation and demonstrates that anti-IgE therapy—specifically with omalizumab—can markedly reduce IgE levels, improve lung function, enhance asthma control, and decrease the frequency of exacerbations. These findings emphasize the clinical value of incorporating immunomodulatory strategies, particularly targeted anti-IgE interventions, into the treatment of moderate to severe allergic asthma.
Publish Date	2025-11-17 03:52
Citation	<p>Agussalim A, Citrawati C, Adam A. Role of IgE cells in the exacerbation and management of asthma: An experimental study. <i>World J Immunol</i> 2025; 15(1): 111119</p>
URL	https://www.wjgnet.com/2219-2824/full/v15/i1/111119.htm
DOI	https://dx.doi.org/10.5411/wji.v15.i1.111119

Full Article (PDF)	WJI-15-111119-with-cover.pdf
CONSORT 2010 Statement	111119-CONSORT-2010-statement.pdf
Manuscript File	111119_Auto_Edited_021019.docx
Answering Reviewers	111119-answering-reviewers.pdf
Audio Core Tip	111119-audio.mpeg
Biostatistics Review Certificate	111119-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	111119-conflict-of-interest-statement.pdf
Copyright License Agreement	111119-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	111119-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	111119-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	111119-non-native-speakers.pdf
Peer-review Report	111119-peer-reviews.pdf
Scientific Misconduct Check	111119-scientific-misconduct-check.png
Scientific Editor Work List	111119-scientific-editor-work-list.pdf
CrossCheck Report	111119-crosscheck-report.pdf