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11/14/2025 8:29:45 AM | Browse: 21 | Download: 53
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Received |
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2025-06-26 10:03 |
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Peer-Review Started |
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2025-06-30 00:43 |
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To Make the First Decision |
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Return for Revision |
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2025-08-08 07:55 |
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Revised |
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2025-08-18 05:23 |
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Second Decision |
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2025-09-17 07:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-24 08:56 |
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Articles in Press |
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2025-09-24 08:56 |
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Publication Fee Transferred |
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2025-08-25 15:44 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-30 10:26 |
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Publish the Manuscript Online |
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2025-11-14 08:23 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Basic Study |
| Article Title |
RRM2 attenuates the renal tubular ferroptosis in diabetic kidney disease through PI3K/Akt/Nrf2 pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chang-Chun Gao, Fen-Fen Ding and Xia Jiang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Xia Jiang, MD, Principal Investigator, Department of Nephrology, Nantong Rehabilitation Hospital (Nantong Second People's Hospital), Department of Nephrology, Nantong Rehabilitation Hospital (Nantong Second People's Hospital), No. 298 Xinhua Road, Chongchuan District, Nantong City-226000, Jiangsu Province, China., Nantong 226000, Jiangsu Province, China. orange1976@126.com |
| Key Words |
Type 2 diabetes mellitus; Diabetic nephropathy; Ribonucleotide reductase regulatory subunit M2; Oxidative stress; ferroptosis; PI3K/Akt pathway; Renal tubular cells |
| Core Tip |
Ribonucleotide reductase regulatory subunit M2 (RRM2) mitigates diabetic kidney disease (DKD) by inhibiting renal tubular ferroptosis via the PI3K/Akt/Nrf2 pathway. Elevated RRM2 levels in patients with type 2 diabetes mellitus are correlated with disease progression. Overexpression reduced oxidative stress, enhanced antioxidant markers [superoxide dismutase, glutathione (GSH), and GSH peroxidase 4], and suppressed ferroptosis (lower malondialdehyde and Fe2+ levels). RRM2 also activates PI3K/Akt signaling and promotes cell survival. Targeting RRM2 may offer therapeutic potential for preventing DKD progression. |
| Publish Date |
2025-11-14 08:23 |
| Citation |
<p>Gao CC, Ding FF, Jiang X. RRM2 attenuates the renal tubular ferroptosis in diabetic kidney disease through PI3K/Akt/Nrf2 pathway. <i>World J Diabetes</i> 2025; 16(11): 111223</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i11/111223.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i11.111223 |
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