Publication Name	World Journal of Orthopedics
Manuscript ID	111242
Country	China

Received	2025-06-27 02:34
Peer-Review Started	2025-06-27 02:34
To Make the First Decision
Return for Revision	2025-07-29 09:36
Revised	2025-08-10 12:00
Second Decision	2025-10-20 02:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-20 06:34
Articles in Press	2025-10-20 06:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-11-07 01:28
Publish the Manuscript Online	2025-11-14 07:35

ISSN	2218-5836 (online)
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Category	Orthopedics
Manuscript Type	Editorial
Article Title	Targeting neutrophil extracellular traps: A novel strategy for treating heterotopic ossification
Manuscript Source	Invited Manuscript
All Author List	Chen-Yu Song, Hong-Ping Yu, Fei-Yan Mu, Jing-Shun Lu, Min Yang, Meng-Han Chang and Kai-Yang Wang
Funding Agency and Grant Number
Corresponding Author	Kai-Yang Wang, MD, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 389 Xincun Road, Shanghai 200233, China. ortho_wang@163.com
Key Words	Neutrophil; Neutrophil extracellular traps; Heterotopic ossification; Molecular mechanisms; Therapeutic strategy; Research progress
Core Tip	The role of neutrophils and neutrophil extracellular traps (NETs) in the pathogenesis of heterotopic ossification (HO) has been extensively studied. Neutrophils accelerate the progression of HO through multiple molecular mechanisms, including upregulating the expression levels of bone morphogenetic protein, interleukin-1α and transforming growth factor β, leading to osteogenic differentiation of mesenchymal stem cells. Meanwhile, the presence of NETs causes the local area to remain in persistent inflammation, which provides a suitable microenvironment for bone formation. By transplanting umbilical cord mesenchymal stem cells and applying batroxobin, QBM076, necrosulfonamide and peptidylarginine deaminase 4 to target neutrophils or NETs, which can play a positive role in the treatment of HO. The therapeutic potential of NETs for addressing HO warrants further investigation in future studies.
Publish Date	2025-11-14 07:35
Citation	<p>Song CY, Yu HP, Mu FY, Lu JS, Yang M, Chang MH, Wang KY. Targeting neutrophil extracellular traps: A novel strategy for treating heterotopic ossification. <i>World J Orthop</i> 2025; 16(11): 111242</p>
URL	https://www.wjgnet.com/2218-5836/full/v16/i11/111242.htm
DOI	https://dx.doi.org/10.5312/wjo.v16.i11.111242

Full Article (PDF)	WJO-16-111242-with-cover.pdf
Manuscript File	111242_Auto_Edited_015701.docx
Answering Reviewers	111242-answering-reviewers.pdf
Audio Core Tip	111242-audio.m4a
Conflict-of-Interest Disclosure Form	111242-conflict-of-interest-statement.pdf
Copyright License Agreement	111242-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	111242-non-native-speakers.pdf
Peer-review Report	111242-peer-reviews.pdf
Scientific Misconduct Check	111242-scientific-misconduct-check.png
Scientific Editor Work List	111242-scientific-editor-work-list.pdf
CrossCheck Report	111242-crosscheck-report.pdf