| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Physiology |
| Manuscript Type |
Review |
| Article Title |
Role of physical exercise, vagal nerve stimulation, and vagotomy in inflammatory bowel disease
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Alda Cassia Alves da Silva, Juliana Soares Severo, Brenda Lois Barros dos Santos, Heron Silva Soares, Jorddam Almondes Martins, Rodrigo Soares Pereira Lima, Kalinne Kelly Lima Gadelha, Francisco Leonardo Torres-Leal, Paulo Correia-de-Sá, Pedro Jorge Caldas Magalhães, Armênio Aguiar Santos and Moisés Tolentino Bento da Silva |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Moisés Tolentino Bento da Silva, Assistant Professor, Professor, Research Assistant Professor, Laboratory of Physiology, Center for Drug Discovery and Innovative Medicines/RISE-Health: Health Research Network, Department of Immuno-Physiology and Pharmacology, School of Medicine and Biomedical Science, University of Porto, Jorge Viterbo Ferreira Street, 228, Porto 4050-313, Portugal. mtsilva@icbas.up.pt |
| Key Words |
Physical exercise; Vagus nerve stimulation; Subdiaphragmatic vagotomy; Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis |
| Core Tip |
The vagus nerve plays a central role in gut-brain communication and the modulation of gastrointestinal inflammation through the cholinergic anti-inflammatory pathway. In this review, we explore the distinct and complementary effects of physical exercise, vagal nerve stimulation, and vagotomy in inflammatory bowel disease. While physical exercise emerges as a non-pharmacological strategy capable of enhancing vagal tone and releasing anti-inflammatory myokines, vagal nerve stimulation offers direct neuromodulation of immune responses and mucosal integrity. In contrast, vagotomy disrupts parasympathetic signaling and exacerbates intestinal inflammation. Understanding how these interventions impact the vagus nerve and immune homeostasis provides insight into novel therapeutic approaches for inflammatory bowel disease management. |
| Publish Date |
2025-10-14 07:41 |
| Citation |
<p>da Silva ACA, Severo JS, dos Santos BLB, Soares HS, Martins JA, Lima RSP, Gadelha KKL, Torres-Leal FL, Correia-de-Sá P, Magalhães PJC, Santos AA, da Silva MTB. Role of physical exercise, vagal nerve stimulation, and vagotomy in inflammatory bowel disease. <i>World J Gastroenterol</i> 2025; 31(38): 111252</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i38/111252.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i38.111252 |
