Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	111264
Country	China

Received	2025-06-26 04:08
Peer-Review Started	2025-06-26 04:08
To Make the First Decision
Return for Revision	2025-07-10 05:55
Revised	2025-07-13 12:42
Second Decision	2025-09-24 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-24 07:27
Articles in Press	2025-09-24 07:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-11-05 00:32
Publish the Manuscript Online	2025-11-14 00:56

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Precision medicine advances in pancreatic cancer driven by genomic and molecular alterations
Manuscript Source	Invited Manuscript
All Author List	Xiang Li, Yan Jiao and Ya-Hui Liu
Funding Agency and Grant Number
Corresponding Author	Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. yahui@jlu.edu.cn
Key Words	Pancreatic ductal adenocarcinoma; Precision medicine; Kirsten rat sarcoma viral oncogene homolog mutation; Breast cancer susceptibility gene mutation; Genomic profiling; Targeted therapy; Tumor mutational burden
Core Tip	This review highlights the transformative impact of precision medicine in pancreatic ductal adenocarcinoma by focusing on clinically relevant genomic and molecular alterations such as Kirsten rat sarcoma viral oncogene homolog and breast cancer susceptibility gene mutations, rare actionable fusions, and co-mutational signatures. It emphasizes the importance of integrating routine molecular profiling into clinical workflows to guide targeted therapies and personalized treatment strategies.
Publish Date	2025-11-14 00:56
Citation	<p>Li X, Jiao Y, Liu YH. Precision medicine advances in pancreatic cancer driven by genomic and molecular alterations. <i>World J Gastrointest Oncol</i> 2025; 17(11): 111264</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i11/111264.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i11.111264

Full Article (PDF)	WJGO-17-111264-with-cover.pdf
Manuscript File	111264_Auto_Edited_062506.docx
Answering Reviewers	111264-answering-reviewers.pdf
Audio Core Tip	111264-audio.mp3
Conflict-of-Interest Disclosure Form	111264-conflict-of-interest-statement.pdf
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Non-Native Speakers of English Editing Certificate	111264-non-native-speakers.pdf
Peer-review Report	111264-peer-reviews.pdf
Scientific Misconduct Check	111264-scientific-misconduct-check.png
Scientific Editor Work List	111264-scientific-editor-work-list.pdf
CrossCheck Report	111264-crosscheck-report.pdf