Publication Name	World Journal of Gastroenterology
Manuscript ID	111307
Country	Mexico

Received	2025-06-27 02:51
Peer-Review Started	2025-06-27 02:51
To Make the First Decision
Return for Revision	2025-07-15 10:30
Revised	2025-07-24 22:16
Second Decision	2025-09-23 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-23 06:58
Articles in Press	2025-09-23 06:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-10-21 02:42
Publish the Manuscript Online	2025-10-27 08:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Growth differentiation factor 11 modulates metabolism, mitigating the pro-tumoral behavior provided by M2-like macrophages in hepatocellular carcinoma-derived cells
Manuscript Source	Invited Manuscript
All Author List	Alejandro Escobedo-Calvario, Lisette Chávez-Rodríguez, Verónica Souza-Arroyo, Leticia Bucio-Ortiz, Roxana U Miranda-Labra, Felipe Masso, Araceli Páez-Arenas, Rogelio Hernández-Pando, Jens Marquardt, María Concepción Gutiérrez-Ruiz and Luis E Gomez-Quiroz
Funding Agency and Grant Number
Corresponding Author	Luis E Gomez-Quiroz, PhD, Department of Ciencias de la Salud, Universidad Autónoma Metropolitana Iztapalapa, No. 186 San Rafael Atlixco, Mexico City 09340, Ciudad de México, Mexico. legq@xanum.uam.mx
Key Words	Hepatocellular carcinoma; Growth differentiation factor 11; Tumor-associated macrophages; M2-like macrophages; Tumor immune microenvironment
Core Tip	Hepatocellular carcinoma (HCC) is an aggressive tumor, and the infiltration of tumor-associated macrophages or M2 macrophages increases aggressiveness. We need therapies to mitigate this pathology in the immune context. In the present study, our in vitro model demonstrates that growth differentiation factor 11 (GDF11) counteracts the pro-tumorigenic properties of M2-like macrophages. This was shown in the reduction of cluster of differentiation 206; furthermore, it induces changes in metabolism and the redox state. Conditioned media from GDF11-treated M2-like macrophages possessed changes in their cytokine profile that neutralized the proliferation and migration of HCC cells, demonstrating that GDF11 alters the pro-tumoral properties of macrophages. This study suggests that mitigating tumor-associated macrophages may be an effective strategy for controlling HCC.
Publish Date	2025-10-27 08:08
Citation	<p>Escobedo-Calvario A, Chávez-Rodríguez L, Souza-Arroyo V, Bucio-Ortiz L, Miranda-Labra RU, Masso F, Páez-Arenas A, Hernández-Pando R, Marquardt J, Gutiérrez-Ruiz MC, Gomez-Quiroz LE. Growth differentiation factor 11 modulates metabolism, mitigating the pro-tumoral behavior provided by M2-like macrophages in hepatocellular carcinoma-derived cells. <i>World J Gastroenterol</i> 2025; 31(40): 111307</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i40/111307.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i40.111307

Full Article (PDF)	WJG-31-111307-with-cover.pdf
Manuscript File	111307_Auto_Edited_062834.docx
Answering Reviewers	111307-answering-reviewers.pdf
Audio Core Tip	111307-audio.wav
Biostatistics Review Certificate	111307-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	111307-conflict-of-interest-statement.pdf
Copyright License Agreement	111307-copyright-assignment.pdf
Institutional Review Board Approval Form or Document	111307-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	111307-non-native-speakers.pdf
Supplementary Material	111307-supplementary-material.pdf
Peer-review Report	111307-peer-reviews.pdf
Scientific Misconduct Check	111307-scientific-misconduct-check.png
Scientific Editor Work List	111307-scientific-editor-work-list.pdf
CrossCheck Report	111307-crosscheck-report.pdf