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11/20/2025 8:14:36 AM | Browse: 13 | Download: 41
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Received |
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2025-06-30 08:02 |
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Peer-Review Started |
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2025-06-30 08:02 |
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To Make the First Decision |
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Return for Revision |
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2025-09-03 06:50 |
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Revised |
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2025-09-14 12:57 |
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Second Decision |
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2025-10-21 02:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-10-21 06:25 |
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Articles in Press |
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2025-10-21 06:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-10 14:26 |
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Publish the Manuscript Online |
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2025-11-20 07:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wei-Wei Dong, Tao Liu, Li-Xia He and Wen-Ting He |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Program of Gansu Province |
No. 23JRRA1015 |
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| Corresponding Author |
Wen-Ting He, The Second Hospital and Clinical Medical School, Lanzhou University, No. 82 Cuiyingmen, Chengguan District, Lanzhou 730030, Gansu Province, China. hewt@lzu.edu.cn |
| Key Words |
Inflammatory bowel disease; Pyroptosis; Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3; Caspase-1; Gasdermin D; Pyroptosis inhibitors |
| Core Tip |
This review examines pyroptosis as a pivotal mechanism in inflammatory bowel disease (IBD) pathogenesis, driving inflammation and tissue damage. It evaluates therapeutic strategies targeting pyroptosis pathways, emphasizing their potential to modulate disease progression. Key challenges including drug specificity, delivery, and safety are analyzed, alongside opportunities for combination therapies. The discussion highlights the need for precision approaches and improved translational models to advance pyroptosis-targeted treatments for IBD. Future directions focus on overcoming current limitations to optimize clinical outcomes. |
| Publish Date |
2025-11-20 07:56 |
| Citation |
<p>Dong WW, Liu T, He LX, He WT. Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach. <i>World J Gastroenterol</i> 2025; 31(43): 111358</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i43/111358.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i43.111358 |
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