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12/23/2025 7:33:40 AM | Browse: 89 | Download: 378
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Received |
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2025-07-09 08:48 |
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Peer-Review Started |
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2025-07-09 08:48 |
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First Decision by Editorial Office Director |
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2025-08-04 07:43 |
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2025-08-04 07:43 |
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Revised |
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2025-08-19 09:54 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-13 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-13 09:10 |
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Articles in Press |
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2025-11-13 09:10 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-05 08:55 |
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Publish the Manuscript Online |
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2025-12-23 06:25 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
Group-specific component and 25-hydroxylase gene polymorphisms in nasopharyngeal carcinoma: Associations with susceptibility and radiotherapy response
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Liu Liu, Dian-Yu Shi, Jie Tan, Shan Xu and Chao-Ran Liu |
| Funding Agency and Grant Number |
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| Corresponding Author |
Chao-Ran Liu, PhD, Researcher, Department of Otolaryngology-Head and Neck Surgery, Longhua District People's Hospital, No. 38 Jianshe East Road, Longhua District, Shenzhen 518110, Guangdong Province, China. chaoranliuszlhrmyy@163.com |
| Key Words |
Group-specific component protein; 25-hydroxylase; Single nucleotide polymorphism; Nasopharyngeal carcinoma; Susceptibility; Radiotherapy response |
| Core Tip |
This study reveals that polymorphisms in the vitamin D-binding protein gene [group-specific component (GC), rs4588] and 25-hydroxylase gene (CYP2R1) (rs12794714) are associated with nasopharyngeal carcinoma (NPC) susceptibility and radiotherapy response, particularly in individuals with sufficient serum 25-hydroxyvitamin D levels. The GC rs4588 TT genotype increases NPC risk, while the CYP2R1 rs12794714 AA genotype predicts radiotherapy resistance. These findings highlight the interplay between genetic predisposition and vitamin D status, offering new strategies for precision prevention and personalized treatment in NPC. |
| Publish Date |
2025-12-23 06:25 |
| Citation |
Liu L, Shi DY, Tan J, Xu S, Liu CR. Group-specific component and 25-hydroxylase gene polymorphisms in nasopharyngeal carcinoma: Associations with susceptibility and radiotherapy response. World J Clin Oncol 2025; 16(12): 111544 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i12/111544.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i12.111544 |
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